PPP Winter Midterm Review Sheet

PPP Winter Midterm Review Sheet - NSAIDs Eicosanoids...

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Eicosanoid-Based Drug (PG) Medical Application Dinoprostone (PGE 2 ) Midtrimester abortion, cervical ripening Misoprostol (PGE 1 analog) Gastric cytoprotection, termination of early preg (< 7 weeks) Alprostadil (PGE 1 ) Male impotence, maintenance of patent ductus arteriosis Epoprostenol (PGI 2 ) (Treprostrinil, Iloprost) Pulm hyper tension Latanoprost (PGF 2a analog) (Bmiatoprost, Travoprost) Glaucoma (open angle) Lubiprostone (PGE 1 analog) Constipation 1
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Heavy Metals Metal What It Does Treatment Lead Acute ab cramps, vomiting, black stool Chronic muscle weakness, CNS issues (encephalopathy), anemia EDTA (iv or im) Dimercaprol (im) Succimer (po) Penicillamine (po) Mercury (elemental Hg completely absorbed in lungs, salt Hg 2+ is mostly accumulated in kidneys, organic Hg readily absorbed in GI) Elemental Acute = weakness, chills, metallic taste, nausea, cough Chronic = more severe CNS effects – excitability, tremors, anger, gingivitis Salt Acute = ashen-gray mucosa of mouth, pharynx, intestines with intense pain, loosened teeth, renal toxicity Chronic = acrodynia (‘pink disease’) Organic Mostly CNS, long term = paralysis Dimercaprol (im) Succimer (po) Penicillamine (po) Arsenic (mostly GI tract absorption) CV = hypotension, arrhythmia, CHF GI = mild cramp, diarrhea Kidneys = tubular necrosis Dimercaprol (im) Succimer (po) Penicillamine (po) 2
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Skin = major target organ (hyperpigmentation) CNS = peripheral neuropathy, muscular atrophy Blood = anemia (bone marrow) Liver = necrosis, cirrhosis (death) Cancer = skin cancer Cadmium (cigarette smoke, so mostly lungs)
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PPP Winter Midterm Review Sheet - NSAIDs Eicosanoids...

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