Principles of Pharmacodynamics (Peace)

Principles of Pharmacodynamics (Peace) - 22/09/201015:01:00...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
22/09/2010 15:01:00 Definitions Potency o Drug X more potent than Drug Y cuz it produces its affect at a lower  concentration Efficacy o Drug X is more efficacious than Drug Y because it produces a higher  effect EC50  o Concentration of a drug that produces half of the measurable effect o Same as disassociation constant of drug/receptor complex Cometetive inhibitors shifts % effect vs [agonist] curve to the right o Sits in the same site as the ligand o Increasing the amt of the agonist allows you to overcome the effect of  the inhibitor and get back up to full response Noncompetetive inhibitors depress the % effect vs [agonist] curve  o i.e. Achetylcholinesterase – inhibitors of acetylcholine Factors influencing drug response Prescribed dose o Med errors o Pt compliance Administered dose o Rate and extent of absorption
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
o Body size and composition o Distribution in body fluids  o Binding in plasma and tissues o Rae of met and excretion Concentration at sits of action o Physiological variables  o Pathological factors – disease alters drug effect o Genetic factors o Interaction with other drugs o Development of tolerance and desensitization Drug Effects o Drug-receptor interaction o Functional state of targeted system – i.e if don’t have defect, than drug  used to treat that defect will not have an effect o Selectivity of drug, propensity to produce unwanted effects o Placebo effects o Resistance (anti-microbial agents and hormones) Kinds of drugs and drug action Physical (osmotic agents – physical presence of drug) Chemical (antacids – neutralize acid in the stomach) Chemical prodrugs (Nitric oxide donors – drug needs to be activated to nitric  oxide) Receptor agonists and antagonists
Background image of page 2
Enzyme substrates and inhibitors Biologicals (enzymes, antibodies, vaccines) Physiological Drug receptors Mostly proteins o Focus on GPCR Beta adrenergic receptors – ligands=NE, Epi, DA Muscarinic cholinergic receptors – ligands=Ach Eiconanoid receptors Thrombin receptors o Ion channels Ligand-gated Sodium channel in muscle that activates muscle  contraction that the muscarinic receptor activates via Ach Voltage-gated Ca channel – opens letting calcium into cell to initiate  cardiac contraction Transmembrane enzymes EGFR Ligands can bind extracellularly or intracellularly Nuclear Receptors (Cytosolic and when bind ligand, they tend to 
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 09/14/2011 for the course PHARM pp taught by Professor Staff during the Spring '11 term at UCSD.

Page1 / 11

Principles of Pharmacodynamics (Peace) - 22/09/201015:01:00...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online