Chap 16 Outline - CHAPTER 16 - THE MOLECULAR BASIS OF...

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CHAPTER 16 - THE MOLECULAR BASIS OF INHERITANCE. Objectives 1. List the three components of a nucleotide. 2. Distinguish between deoxyribose and ribose. 3. List the nitrogen bases found in DNA, and distinguish between pyrimidine and purine. 4. Explain how Watson and Crick deduced the structure of DNA, and describe what evidence they used. 5. Explain the “base-pairing rule” and describe its significance. 6. Describe the structure of DNA, and explain what kind of chemical bond connects the nucleotides of each strand and what type of bond holds the two strands together. 7. Explain, in own words, semiconservative replication. 8. Describe the process of DNA replication, and explain the role of enzymes. 9. Define antiparallel, and explain why continuous synthesis of both DNA strands is not possible. 10. Distinguish between the leading strand and the lagging strand. 11. Explain lagging strand synthesis when DNA polymerase can add nucleotides only to the 3’ end. 12. Explain the role of DNA polymerase, ligase, and repair enzymes in DNA proofreading and repair. 13. Explain the possible significance of telomerase in germ cells and cancerous cells. 14. Compare a bacterial chromosome and a eukaryotic chromosome. 15. Describe how the packing of chromatin changes during the course of the cell cycle. 16. Distinguish between heterochromatin and euchromatin. Keywords Bacteria chromatin deoxyribose DNA ligase DNA polymerase double helix euchromatin helicase heterochromatin histone lagging strand leading strand mismatch repair nucleoid region Okazaki fragment origin of replication polymerase primer pyrimidine radioactive isotope replication fork semiconservative model telomerase telomere template strand X-ray crystallography Outline A. DNA as the Genetic Material 1. Watson and Crick discovered the double helix by building models to conform to X- ray data 2. DNA is unique in its ability to direct its own replication. Important in cell division. 3.
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This note was uploaded on 09/14/2011 for the course BIOL 2301 taught by Professor Staff during the Spring '11 term at Lone Star College System.

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Chap 16 Outline - CHAPTER 16 - THE MOLECULAR BASIS OF...

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