CVBlockAbridged - Autonomic Nervous System Nervous System...

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Autonomic Nervous Syste Nervous System CNS PNS Brain *cerebral hemisphere *brain stem *cerebellum Spinal Cord *cervical *thoracic *lumbar *sacral Cranial Nerves CN1-12 to/from brainstem (3,7,9,10) Spinal Nerves *C1-8 *T1-12 *L1-5 *S1-5 Nerve = bundle of fibers (axons) Mixed Nerve = afferent + efferent S S T T E ANS Autonomic Nervous System Sympathetic Sympathetic T1-L2 T1-L2 CN3,7, CNS Preganglion n Peripheral ganglion ACh ACh Nn, M1 Nn, M1 ACh Synpase Paravertebral Paravertebral Prevertebral Adrenergic Cholinergic Pupil Dilation, far vision HR, BP increase Piloerection Bronchiodilation α1 (EPI, NE) α2 (EPI, NE) β1 (EPI, NE) β2 (EPI) N G q G s G s SM CONTRT visceral, veins; Contract GI and Contract radial dilatory muscle Stimulate heart, increased Renin SM RELAX Vasodilation in skeletal muscle; Bronchodilation; GI and urinary motility decrease, relax cilliary muscle G q → Phospholipase C → IP3 → release Ca2+ from SR → Ca2+ Calmodu → DAG → Ca2+ Calmodulin → MLCK → P+myo G s → ↑activation of PKA → ↑phospho of MLCK → G i → ↓ → ↓activation of PKA → ↓phospho of MLCK → Postganglion ACh NE Effector M3 α , β EPI NE To bloodstream NEJ NEJ Exclusively sympathetic= blood vessels, sweat glands, pilomotor, adrenal medulla Sweat Glands P Ra c tem 10-12-2010 Neurons Afferent (sensory) Efferent (motor) Somatic Sensory Visceral Sensory Somatic Motor Visceral Motor Touch Temperature External stimuli Internal organs Glands Skeletal muscle Movement Heart Rate Smooth muscle contraction SNS Somatic Nervous System Parasympathetic ,9,10 S2-4 Brain Spinal Cord sory Neuron ACh elimination by ACh Esterase (AChE) b Fast = short duration NE elimination by NET reuptake n N m M 1 M 2 M 3 G q G i G q @ nerves; to modulate transmitter release and ganglionic transmission (peripheral ganglia) @heart, nerve, smooth muscle; decrease HR, presynaptic inhibition Glandular secretion; sweating; vasodilation at smooth muscles smooth musc contract lin → MLCK → P+myosin osin → SM contraction → ↓activation of MLCK → ↓phospho of MLC → SM relaxation → ↓activation of MLCK → ↑phospho of MLC → SM contraction ACh ACh ACh Nn, M1 Nm M2, M3 NEJ NMJ Senso Near vision HR, BP decrease GI tract active Bronchioconstriction Skeletal Muscles Predominantly parasympathetic= GI, urinary, eye (recycles NE) Slow= prolonged effect RECEPTORS Eye muscles: Ciliary Muscle= relax b far vision Pupillae Sphincter= contract b miosis adial Dilator Muscle= ontract b mydriasis
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Autonomic Tone and Baro Block of ANS Tone by a N N Antagonist Airway diameter with basal smooth muscle tone Add small amount of resting sympathetic bronchodilator tone Sweating in absence of sweat gland stimulation Add small amount of resting sympathetic cholinergic tone stimulate sweating Sweating with normal ANS tone “Intrinsic HR” Add small amount of resting sympathetic tone to increase HR (100/min) (110/min) Diameter of blood vessel with basal smooth muscle tone Add moderate amount of rest sympathetic vasoconstricto tone Diameter of blood vessel wi normal ANS tone
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This note was uploaded on 09/14/2011 for the course PHARM cs taught by Professor Staff during the Spring '11 term at UCSD.

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CVBlockAbridged - Autonomic Nervous System Nervous System...

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