DrugList11

DrugList11 - Cardiovascular System 1 Drug List 1 Fall 2010...

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Cardiovascular System 1 Drug List 1 Fall 2010 Nora Laiken, PhD Drug List 1 a, b Cholinergic Pharmacology, Adrenergic Pharmacology Cholinergic Pharmacology Drugs affecting ACh synthesis, storage, and exocytosis Inhibition of exocytosis of ACh: botulinum toxin [ BOTOX ] Drugs that interact with nAChRs Agonists nicotine Antagonists N M selective: neuromuscular blocking agents Competitive agents: D-tubocurarine Depolarizing agents: succinylcholine N N selective: ganglionic blocking agents (competitive, noncompetitive) Drugs that interact with mAChRs Agonists Choline esters: bethanechol Natural alkaloids: pilocarpine Antagonists Belladonna alkaloids and derivatives: atropine, scopolamine [ TRANSDERM SCOP ] Drugs that inhibit AChE (anti-ChEs) Noncovalent agents : edrophonium Carbamoylating agents (“-stigmines”): physostigmine , neostigmine (N + ) Phosphorylating agents : echothiophate , malathion AChE reactivating agent : pralidoxime (2-PAM) _________ a On both the weekly online quizzes and the Cardiovascular System 1 exam, students will mainly be responsible for understanding the mechanisms and pharmacological effects of the drug classes listed here rather than the specific properties of particular drugs. For some of the drug classes, important prototype examples are listed in bold italics ; you should know these “core drugs.” The Alphabetical Drug List on pp 3-4 includes additional drugs, listing most drugs mentioned in the Cholinergic Pharmacology and Adrenergic Pharmacology lectures. Again,
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DrugList11 - Cardiovascular System 1 Drug List 1 Fall 2010...

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