Lecture 03 - Drug-Receptor Interactions

Lecture 03 - Drug-Receptor Interactions - o You have the...

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Lecture 03 - Drug Receptor Interactions - Goal: To understand dose-response relationships and how these are affected by antagonists o - Beta 2 would increase cAMP and Brochodilation and asthma symptoms are relieved things we can measure!! Law of Mass Action - o Response = biological - D and R associate at rate proportional to both [D] and [R] - DR dissociates at rate proportional to [DR] only - Reversible o This depends on how much of each you are adding! - The rate by which our drug binds to receptor is defined by the rate constant o This depends on how well the drug binds to the receptor o If the receptor is extremely accessible – the fastest it can bind it would be a diffusion limited reaction (big rate constant) o If you have a binding pocket that is deep within the receptor and there are many things in the way of the drug getting into the receptor -- (small rate constant) - When drugs bind to receptor – it does not get modify in any way it is only depend on how much drugs and how much receptor we have - The rate at which they come together is dependent on the rate constant
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Lecture 03 - Drug-Receptor Interactions - o You have the...

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