Lecture 06 - Adrenergic

Lecture 06- - Director LEARNING OBJECTIVES Vocabulary Tyrosine DOPA Dopamine(DA Norepinephrine(NE Epinephrine(Epi Synthetic and degradative enzymes

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Director LEARNING OBJECTIVES Vocabulary Tyrosine DOPA Dopamine (DA) Norepinephrine (NE) Epinephrine (Epi) Synthetic and degradative enzymes for catecholamines NET, ENT VMAT2 b agonists and antagonists a agonists and antagonists Cocaine Amphetamine Tyramine Lecture Outline Catecholamine synthesis, storage, release, and re- uptake Metabolism of catecholamines Actions of catecholamines at receptors; receptor- effector coupling a Agonists and antagonists b Agonists and antagonists Clinical problem The Autonomic Nervous System Catecholamine Biosynthesis Where, exactly, does all this happen? Transmitter Synthesis And Release at an Adrenergic Terminal Release occurs by exocytosis, diffusely at nerve varicosities. A variety of membrane receptors can modulate release, including those stimulated by NE, by other contents of the adrenergic storage granule, and other neurotransmitters such as ACh. To what receptors does NE bind? These receptors can be:
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This note was uploaded on 09/14/2011 for the course PHARM cs taught by Professor Staff during the Spring '11 term at UCSD.

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Lecture 06- - Director LEARNING OBJECTIVES Vocabulary Tyrosine DOPA Dopamine(DA Norepinephrine(NE Epinephrine(Epi Synthetic and degradative enzymes

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