Quiz4Questions789Explanations - Cardiovascular System 1...

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Cardiovascular System 1 Quiz Answers Fall 2010 Quiz 4 – Questions 7-9 Explanations of the Answers 7. Drug W markedly increases the diastolic pressure (DP), increases the pulse pressure (PP), and decreases the HR. Looking at just the DP and HR effects, only NE and phenylephrine ( α agonist) are possible answers (in both cases, the decrease in HR is a reflex response to the increase in BP). ACh, EPI (in a physiological dose), and isoproterenol decrease DP, and all of these drugs increase the HR (in the case of ACh, this is a reflex response to the fall in BP). Looking next at the PP effect, NE is a more likely answer than phenylephrine. Recall that the major determinant of PP is inotropic state . NE, but not phenylephrine, increases the inotropic state ( β 1 effect) and therefore increases the PP. Thus, Drug W is NE (choice C) . 8. Drug X decreases the BP and increases the HR. Of the listed choices, only trimethaphan (N N antagonist) and phentolamine ( α antagonist) are possible answers (the similarity between the responses to these two antagonists was discussed in the Physiological Tracings TBL; note that phentolamine’s effect on HR is a
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This note was uploaded on 09/14/2011 for the course PHARM cs taught by Professor Staff during the Spring '11 term at UCSD.

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Quiz4Questions789Explanations - Cardiovascular System 1...

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