receptors_and_drugs

receptors_and_drugs - Recepto r Alpha1 (NE) G protein...

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Recepto r G protein Location effect Agonists antagonist Alpha1 (NE) Gq IP3/Ca Smooth muscle (constriction) Vasculature Eye: radial dilator muscle Sphincters of GI and bladder pilomotor Excitatory/contraction Vasoconstriction ( BP) Myadriasis (dilation) Decreased elimination piloerection Alpha 1-selective: Phenylephrine Alpha 1-selective: Prazosin Non-selective: Phentolamine (these BP) Alpha 2 Gi cAMP SM GI tract Vasoconstriction Ach release in GI Alpha 2-selective: a-methyldopa, clonidine Non-selective: phentolamine Beta1 Gs cAMP Heart (cardiac muscle) --SA node --AV node --ventricular muscle Kidney (granular cells) Excitatory ( BP) HR cond vel contractility renin secretion Non-selective Isoproterenol B1-selective: dobutamine Nonselective: Propranolol, pindolol, carvediol B1-selective: Atenolol, metropolol (A-M –olol act on Beta1) Beta2 (EPI) Gs cAMP Smooth muscle --skeletal muscle --bronchial sm --walls of GI tract and bladder (alpha2) eye: ciliary muscle
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This note was uploaded on 09/14/2011 for the course PHARM cs taught by Professor Staff during the Spring '11 term at UCSD.

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receptors_and_drugs - Recepto r Alpha1 (NE) G protein...

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