Summary_of_ANS_receptors_and_neurotransmitters

Summary_of_ANS_receptors_and_neurotransmitters -...

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Sympathetic Alpha 1 Adrenergic Gq--increased [Ca2+]i smooth muscle ( contraction) vasculature (constrictions) eye:  radial dilator muscle (mydriasis--aka pupillary dilation) spinchters of GI and urinary tracts (decreases elimination) pilomotor (piloerection) MAJOR VASOCONSTRICTOR Parasympathetic M1 Cholinergic Gq/11--IP3, DAG cascade Nerves (modulate transmitter release and ganglionic transmission) Neurotransmitters NOREPINEPHRINE Effector receptors Alpha 1 Alpha 2 Beta 1
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Alpha 2 Gi--decreased cAMP Smooth muscle (contraction) vasculature (constriction) GI tract nerve terminals (decreased exocytosis of NTs like Ach) M2 Gi/o--decr. cAMP, activate K+ channels Heart (decr. HR, decr. AV nodal conduction)  Nerve (presynaptic inhibition) EPINEPHRINE Alpha 1 Alpha 2 Beta 1 Beta 2
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Beta 1 Beta 2 Gs--increased cAMP Gs--increased cAMP Heart (stimulation) smooth muscle (relaxation) SA node (incr. HR) vasculature (dilation) Atria (incr. contractility or IS)
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Summary_of_ANS_receptors_and_neurotransmitters -...

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