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Lecture 05 - Chart for transport proteins

Lecture 05 - Chart for transport proteins - SCL(solute...

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SCL (solute carrier): second largest group of membrane proteins in humans; nomenclature: Human gene names = caps + italics / protein names = caps + regular Port Functional characteristics Disease/Pharamcology Uniport Glucose transporters Fructose transporter Symport Glucose + galactose transporter Disease : -malabsorption (rare) Pharmacology : -oral rehydration therapy Na+ / Bile salts transport Na+ / Bile salts transport Disease : -diarrhea after ileal resection (common) -idiopathic intestinal bile acid malabsorption syndrome (rare) Pharmacology : -ASBT inhibition can decrease serum cholesterol H+ / Peptides transport Disease : -transports peptide-containing bacterial cell wall products into cells for recognition by innate immune sensors intestinal inflammation Pharmacology : -Facilitating oral uptake of peptidomimetic drugs (penicillin, ACE inhibitors) taking advantage of the peptide bond Antiport Exchanged Cl- and HCO3- Disease: -congential chloride losing diarrhea (rare)
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ATPases transport : (also have F and V 1. P type - Protein phosphorylation during transport 2. ABC type - ATP hydrolysis without phosphorylation - Grouping strictly by sequence relatedness (notfunction) Active ATP-dependent ligand transport across membranes Transpo rter Port Functional characteristics Disease ATP1A P- ATPa ses Na,K -ATPase - Provide driving force for Na+ dependent cotransport ATP2B1 (PMCA1 ) Ca++ ATP4A/ B H,K -ATPase Irreversible inactivation by PPI ATP7A Cu -ATPase - Transport from cytosol to secretory organelles or extracellular space Loss causes Menkes diseases (fatal childhood disorder due to inadequate copper untake and
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