immunology

immunology - T cell Immunity Immunology lecture 11 Joe...

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Unformatted text preview: T cell Immunity Immunology lecture 11 Joe Cantor May 12 th , 2011 Why do we need adaptive immunity? T cell Immunity Circulation Activation Clonal expansion Differentiation Effector function Formation of memory Control of T cell circulation Why are lymph nodes important? Cant have all specific lymphocytes everywhere Nodes bring all tissue __antigens______ to all _immune______cells Tremendous task accomplished with lymph flow Organized anatomy to sort Ag and select responders Defined space for _clonal expansion_________ Place for clonal selection away from sensitive tissues Additional level of control Control of T cell circulation Adhesion molecules Selectins (L-, P-, and E-) = rolling and tethering Integrins ( _LFA1______ , VLA4, etc) = firm adhesion Chemokines Signal through receptors Activate integrins Guide through gradients Nave T cells __L__-selectin LFA-1+ integrin CCR_7___ CCL21 (HEV) CCL19 (Dend. cells) S1P receptor S1P (lymph and blood) Out of cellular space back into blood; when lymphocytes express this receptor pulls them back out of lymph Activated T cells ___-selectin LFA-1+ integrin CCR__ CCL21 (HEV) CCL19 (Dend. cells) S1P receptor S1P (lymph and blood) X X T cell Immunity Circulation Activation Clonal expansion Differentiation Effector function Formation of memory T cell activation Antigen uptake by APC __DCs___________ Macrophages B cells Danger activates APC TLR signals co-stim. molecules APCs travel to LN T cell activation Dendritic cells are best APCs for _naive______ T cells Dendritic cell maturation Phagocytosis of antigens in tissues...
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immunology - T cell Immunity Immunology lecture 11 Joe...

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