immunology

immunology - T cell Immunity Immunology lecture 11 Joe...

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Unformatted text preview: T cell Immunity Immunology lecture 11 Joe Cantor May 12 th , 2011 Why do we need adaptive immunity? T cell Immunity • Circulation • Activation • Clonal expansion • Differentiation • Effector function • Formation of memory Control of T cell circulation Why are lymph nodes important? – Can’t have all specific lymphocytes everywhere – Nodes bring all tissue __antigens______ to all _immune______cells • Tremendous task accomplished with lymph flow – Organized anatomy to sort Ag and select responders – Defined space for _clonal expansion_________ – Place for clonal selection away from sensitive tissues – Additional level of control Control of T cell circulation • Adhesion molecules – Selectins (L-, P-, and E-) = rolling and tethering – Integrins ( _LFA1______ , VLA4, etc) = firm adhesion • Chemokines – Signal through receptors – Activate integrins – Guide through gradients Naïve T cells – __L__-selectin – LFA-1+ integrin – CCR_7___ • CCL21 (HEV) • CCL19 (Dend. cells) – S1P receptor • S1P (lymph and blood) • Out of cellular space back into blood; when lymphocytes express this receptor pulls them back out of lymph Activated T cells – ___-selectin – LFA-1+ integrin – CCR__ • CCL21 (HEV) • CCL19 (Dend. cells) – S1P receptor • S1P (lymph and blood) X X T cell Immunity • Circulation • Activation • Clonal expansion • Differentiation • Effector function • Formation of memory T cell activation • Antigen uptake by APC – __DCs___________ – Macrophages – B cells • “Danger” activates APC – TLR signals – ↑ co-stim. molecules • APCs travel to LN T cell activation • Dendritic cells are best APCs for _naive______ T cells • Dendritic cell maturation – Phagocytosis of antigens in tissues...
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immunology - T cell Immunity Immunology lecture 11 Joe...

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