11Locationrecirculation

11Locationrecirculation - WHERE DO IMMUNE PROCESSES HAPPEN?...

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Unformatted text preview: WHERE DO IMMUNE PROCESSES HAPPEN? April Apperson, UCSD SOM OESS 1˚ lymphoid organs are the sites of leukocyte development. a) B-cells and all other WBC – DC, monocytes, neutrophils, eosinophils, NK cells – develop in the bone marrow. b) T-cells develop and are educated in the thymus. Connective tissue beneath body surfaces (skin or mucosal epithelia) is a common site of infection. •Loose connective tissue contains capillaries, macrophages, dendritic cells (DC) and mast cells and lymphatics. •Infected tissue is the site of the innate response and where effector T-cells and secreted antibodies act. 2˚ lymphoid tissues are sites in which naïve T-cells and B-cells are maintained and respond to antigen through clonal expansion, generating effector and memory lymphocytes. a) Lymph nodes – most common site of adaptive immune responses, and respond to pathogens that are infecting connective tissue beneath skin, mucosa or within organs. b) White pulp of the spleen – responds to pathogens in blood c) Lymphoid nodules of MALT (Peyer’s patches) – respond to ingested pathogens April Apperson, M.S., UCSD SOM OESS 5/6/11 Lymph node worksheet – useful for identifying structures and regions within node and drawing out: •recirculation paths for T-cells and B-cells •antigen delivery and clonal expansion of T-cells and B-cells April Apperson, M.S., UCSD SOM OESS 5/6/11 ...
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11Locationrecirculation - WHERE DO IMMUNE PROCESSES HAPPEN?...

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