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Unformatted text preview: WHERE DO IMMUNE PROCESSES HAPPEN?
April Apperson, UCSD SOM OESS 1˚ lymphoid organs are the sites of leukocyte development.
a) B-cells and all other WBC – DC, monocytes, neutrophils,
eosinophils, NK cells – develop in the bone marrow.
b) T-cells develop and are educated in the thymus.
Connective tissue beneath body surfaces (skin or mucosal
epithelia) is a common site of infection.
•Loose connective tissue contains capillaries, macrophages,
dendritic cells (DC) and mast cells and lymphatics.
•Infected tissue is the site of the innate response and where
effector T-cells and secreted antibodies act. 2˚ lymphoid tissues are sites in which naïve T-cells and B-cells
are maintained and respond to antigen through clonal
expansion, generating effector and memory lymphocytes.
a) Lymph nodes – most common site of adaptive immune
responses, and respond to pathogens that are infecting
connective tissue beneath skin, mucosa or within organs. b) White pulp of the spleen – responds to pathogens in blood
c) Lymphoid nodules of MALT (Peyer’s patches) – respond to ingested pathogens
April Apperson, M.S., UCSD SOM OESS 5/6/11 Lymph node worksheet – useful for identifying structures and regions within node and drawing out:
•recirculation paths for T-cells and B-cells
•antigen delivery and clonal expansion of T-cells and B-cells April Apperson, M.S., UCSD SOM OESS 5/6/11 ...
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- Spring '11