11Pathogenimmuno_correl

11Pathogenimmuno_correl - Patterns of susceptibility to...

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Patterns of susceptibility to infection with immune deficiencies (Numbers in parentheses refer to cases in Cases text; information adapted from Cases text) April Apperson, UCSD SOM OESS Opportunistic infections occur with an absence of functional T-cells = SCID (because need CD4+ T-cells for TD B-cell responses); opportunistic infections result from bacteria, viruses and fungi that normally reside non-pathogenically in our bodies because of ongoing control by cellular immunity, but become pathogenic without that immunity. Typical order of opportunistic infections that appear in an infant or adult: 1) thrush (severe yeast infection) in mouth and diaper area; 2) Pneumocystis carinii (fungus) infection in lungs causing cough; 3) intractable diarrhea due to overgrowth of enteropathic bacilli; 4) adults may also develop Aspergillus (fungus) infection in lungs causing cough Medical emergency because infants (or adult if SCID is acquired) die rapidly from infections even when treated adequately with antibiotics or antivirals. 1) Multiple genetic causes of SCID result in same symptoms and small, dysplastic thymus
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This note was uploaded on 09/14/2011 for the course PHARM imm taught by Professor Staff during the Spring '11 term at UCSD.

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11Pathogenimmuno_correl - Patterns of susceptibility to...

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