Cytokine_overview

Cytokine_overview - OVERVIEW OF CYTOKINE SOURCES AND...

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OVERVIEW OF CYTOKINE SOURCES AND FUNCTIONS April Apperson, UCSD SOM OESS Major cell sources Overview of major cytokine functions Non-lymphocyte Lymphocyte Acting on non-adaptive cells In lymphocyte differentiation TNF α Th1 IL-1 Act on local small vessels – inflammation and recruitment: •dilate arterioles •increase capillary permeability •microclotting of blood helps occlude venules •induce adhesion selectins & ICAMs on endothelial cells Activate DCs and cause their migration to lymph nodes Act on liver to cause acute phase response Act in brain to (indirectly) cause fever IL-6 Th17 •Act on liver to cause acute phase response •Act in brain to (indirectly) cause fever •With TGF β , biases CD4+ differentiation to Th17 Contributes to biasing CD4+ differentiation to Tfh •Contributes to B-cell clonal expansion CXCL8 •Chemoattractant for neutrophils •Induces adhesion integrin on neutrophils (Chemoattractant for effector T-cells) IL-12 Macrophages & DC in response to
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This note was uploaded on 09/14/2011 for the course PHARM imm taught by Professor Staff during the Spring '11 term at UCSD.

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Cytokine_overview - OVERVIEW OF CYTOKINE SOURCES AND...

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