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Unformatted text preview: Im m u n e S y s t e m B a s i c s Cell Type System Lineage Function Location Other Dendritic Cell Innate Myeloid • Antigen-presenting cell • Cytokine secretion • Lymph node • Tissues • Langerhans DC in skin: cross-presents to cytotoxic T-cells and activates helper T-cells • Interstitial DC: presents to helper T- cells and B-cells • Plasmacytooid DC: recognizes viruses and produces type I interferon Macrophage Innate Myeloid • Antigen-presenting cell • Cytokine secretion • Kills bacteria • Lymph node • Tissue • Kupffer cell in liver • Microglial cell in CNS • Alveolar macrophage in lung • Osteoclast in bone Monocyte Innate Myeloid • Precursor to macrophage • Blood • Short lifespan Neutrophil Innate Myeloid • Kills bacteria, fungi • May be involved in wound healing • Blood • Tissue • 12 hour lifespan Eosinophil Innate Myeloid • May help in defense against helminthss/parasites • Blood • Tissue • Involved in drug allergies Basophil Innate Myeloid • Unknown • Blood • Rare Mast cell Innate Myeloid • IgE response elease of granules • Tissue • Involved in allergy Innate Adaptive Time after infection 0-12 hours 1-3 days Humoral Cell- Mediated Components Dendritic cells, macrophages , neutrophils, NK cells, monocytes, eosinophils, basophils, mast cells,NK-T cells, γδ-T Cells, B-1 cells, complement T-cells, NK- cells, macrophages , neutrophils Antibodies, complement Target Extracellular bacteria, parasites, fungi, worms Intracellular bacteria, parasites, fungi, viruses Receptor Patterns or Structural detail of antigens, can • Release of granules containing histamine and other agents Natural Killer Innate Adaptive Lymphoid • Kills infected cells • IFNγ secretion • Blood • Tissue • Lymph node NK-T Innate Adaptive Lymphoid • Uknown • Recognizes lipids presented on CD1 • Blood • Liver • Spleen • TCR+ • NK1.1+ γδ T-cell Innate Adaptive Lymphoid • Unknown • Wound healing • Tumor killing • Blood • Tissue • Lymph node B-1 Cell Innate Adaptive Lymphoid • Peritoneal defense • Peritoneum • CD5+ αβ CD4+ T Adaptive Lymphoid • Cytokine secretion • Blood • Lymph node • Tissue αβ CD8+ T Adaptive Lymphoid • Kills infected cells and tumors • Blood • Lymph node • Tissue B cell Adaptive Lymphoid • Antibody production • Blood • Lymph node • Tissue? Specificity structures shared by microbes (e.g. LPS) also recognize nonmicrobial antigens Receptor Diversity Limited (germline encoded) Diverse (somatic DNA recombination) Receptor distribution Nonclonal: identical receptors on all cells of the same lineage Clonal: clones have distinct specificities and receptors Discriminatin g self from non-self Host cells are not recognized Selection against self-reactive lymphocytes Seocndary response Same as primary response Faster than primary response L y m p h o id T i s s u e s a n d O r g a n Spleen (White pulp) Lymph Node T-cell entry • Central arteriolar sinusoids...
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- Spring '11
- cells, dendritic cells, NK Cells