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Unformatted text preview: Im m u n e S y s t e m B a s i c s Cell Type System Lineage Function Location Other Dendritic Cell Innate Myeloid Antigen-presenting cell Cytokine secretion Lymph node Tissues Langerhans DC in skin: cross-presents to cytotoxic T-cells and activates helper T-cells Interstitial DC: presents to helper T- cells and B-cells Plasmacytooid DC: recognizes viruses and produces type I interferon Macrophage Innate Myeloid Antigen-presenting cell Cytokine secretion Kills bacteria Lymph node Tissue Kupffer cell in liver Microglial cell in CNS Alveolar macrophage in lung Osteoclast in bone Monocyte Innate Myeloid Precursor to macrophage Blood Short lifespan Neutrophil Innate Myeloid Kills bacteria, fungi May be involved in wound healing Blood Tissue 12 hour lifespan Eosinophil Innate Myeloid May help in defense against helminthss/parasites Blood Tissue Involved in drug allergies Basophil Innate Myeloid Unknown Blood Rare Mast cell Innate Myeloid IgE response elease of granules Tissue Involved in allergy Innate Adaptive Time after infection 0-12 hours 1-3 days Humoral Cell- Mediated Components Dendritic cells, macrophages , neutrophils, NK cells, monocytes, eosinophils, basophils, mast cells,NK-T cells, -T Cells, B-1 cells, complement T-cells, NK- cells, macrophages , neutrophils Antibodies, complement Target Extracellular bacteria, parasites, fungi, worms Intracellular bacteria, parasites, fungi, viruses Receptor Patterns or Structural detail of antigens, can Release of granules containing histamine and other agents Natural Killer Innate Adaptive Lymphoid Kills infected cells IFN secretion Blood Tissue Lymph node NK-T Innate Adaptive Lymphoid Uknown Recognizes lipids presented on CD1 Blood Liver Spleen TCR+ NK1.1+ T-cell Innate Adaptive Lymphoid Unknown Wound healing Tumor killing Blood Tissue Lymph node B-1 Cell Innate Adaptive Lymphoid Peritoneal defense Peritoneum CD5+ CD4+ T Adaptive Lymphoid Cytokine secretion Blood Lymph node Tissue CD8+ T Adaptive Lymphoid Kills infected cells and tumors Blood Lymph node Tissue B cell Adaptive Lymphoid Antibody production Blood Lymph node Tissue? Specificity structures shared by microbes (e.g. LPS) also recognize nonmicrobial antigens Receptor Diversity Limited (germline encoded) Diverse (somatic DNA recombination) Receptor distribution Nonclonal: identical receptors on all cells of the same lineage Clonal: clones have distinct specificities and receptors Discriminatin g self from non-self Host cells are not recognized Selection against self-reactive lymphocytes Seocndary response Same as primary response Faster than primary response L y m p h o id T i s s u e s a n d O r g a n Spleen (White pulp) Lymph Node T-cell entry Central arteriolar sinusoids...
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- Spring '11