Antibiotics - LO and Table

Antibiotics - LO and Table - Antibiotic General Class...

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Unformatted text preview: Antibiotic General Class Mechanism Vancomycin Cell Wall D-ala-D-ala changes to D-ala-D-lac (decreases affinity by 1000s) Ampicillin Cell Wall Peptidoglycan (chain terminal) Oxacillin Cefazolin Cell Wall 1 st gen cephalosporin (6-member ring) Cefepime Cell Wall cephalosporin Meropenem Cell Wall Carbapenem E rythromyci n Ribosomal Macrolides -- Clindamycin Ribosomal Macrolides Azithromyci n Ribosomal Macrolides Evade CYP 450 Doxycycline Ribosomal Gentamicin Ribosomal Linezolid Ribosomal Tigecycline Ribosomal Minocycline derivative Amikacin Ribosomal Macrolides Azolide ?? Synercid Ribosomal Streptogramins Metronidazo le DNA synthesis Ciprofloxaci n DNA synthesis DNA gyrases and prevent the ability to super coil DNA Topoisomerase *Cell Wall bactericidal *Ribsome/DNA inhibitors mostly bacteristatic (excpt the aminoglycosides) *Ribosmal MLS group Macrolides, Lincosamides, Streptogramins -- all protein synthesis inhibitors Lecture 10 Antibiotics - Cell Wall Active Agents M I-26b. Define minimum inhibitory concentration (MIC), post-antibiotic effect, and bactericidal vs. bacteriostatic M IC the lowest concentration of antibiotic inhibiting growth bactericidal killing of the bacteria bacteriostatic inhibition of bacteria growth M I-26d. Describe the principles that guide empiric, definitive, and prophylactic antimicrobial therapy M I-26f. Based on the site of a patients infection and medical history, name several drugs of first choice for empiric antimicrobial treatment before microbiological results are available M I-26c. Describe and contrast -lactam, cabepenems, and glycopeptides (vancomycin) antibiotics based on their mechanism of action, side effects, and the development of and strategies for handling resistance M I-26e. Describe pharmacokinetic, site of infection, and host factors that influence the choice of an antimicrobial drug P HARM 405 . Describe the antibiotics that are important in ophthalmology The first aspect the inherit different between gram (+) and (-) o Both have the inner membrane (the membrane that separates the inner bacterial environment from outside o (+) the cell wall/peptidoglycan is thick they can retain the gram stain o (-) thinner but the exterior outer membrane outer peptidoglycan inner membrane o Cell wall layer (+) is exposed to the environment (the gram negative is essential separated by the outer membrane) To lay down new cell wall o Step one: linear polymer has to be synthesized o Step two: there is a structure here penipeptide that attaches itself to the polymer that has 5 AAs This penipeptide has to be crosslinked in the crosslinking reaction o Step three: the polymer is crosslinked into the structure Cell wall The targets to inhibit the cell wall formation has a high therapeutic index B-lactams inhibit the crosslinking reaction in both gram (+) and (-) PBPs carry out the crosslinking reaction (transpeptidation) and...
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Antibiotics - LO and Table - Antibiotic General Class...

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