{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Case1-Aspergillus

Case1-Aspergillus - Case 1 Lydyard Peter Cole Michael...

Info icon This preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
1. What is the causative agent, how does it enter the body and how does it spread a) within the body and b) from person to person? Causative agent Aspergillosis is caused by Aspergillus, a saprophytic, filamentous fungus found in soil, decaying vegetation, hay, stored grain, compost piles, mulches, sewage facilities, and bird excreta. It is also found in water stor- age tanks (for example in hospitals), fire-proofing materials, bedding, pil- lows, ventilation and air conditioning, and computer fans. It is a frequent contaminant of laboratory media and clinical specimens, and can even grow in disinfectants! Although Aspergillus is not the most abundant fungus in the world, it is one of the most ubiquitous. There are more than 100 species of Aspergillus . Although about 10 000 genes have been identified in the Aspergillus genome, none of the gene sets is shared with other fungal pathogens. The cell wall of A. fumigatus contains various polysaccharides (Figure 2). Newly synthesized b (1-3)-glucans are modified and associated to the other cell wall polysaccharides (chitin, galactomannan, and b (1-3)-, b (1-4)-glucan) Case 1 Aspergillus fumigatus A 68-year-old Caucasian man was diagnosed with B-cell chronic lymphocytic leukemia (B-CLL) and received various regimens of chemotherapy. As a patient with chronic leukemia he attended the CLL clinic regularly. Ten years later the patient presented with pneumonia symptoms and was examined by chest CT scan . The results were suggestive of aspergillosis and additional laboratory tests were done. Positive Aspergillus serology allowed the doctors in the clinic to give a diagnosis of A. fumigatus pneumonia. The patient was not neutropenic and his condition improved following an 8-month course of itraconazole followed by voriconazole for 6 months. Two years later the patient was diagnosed with pulmonary aspergillosis. The diagnosis was based on a CT scan, cytology results, and a history of prior infection (Figure 1). He was treated with amphotericin B, monitored by radiography, followed by caspofungin for 9 days, but he died 2 days later of drug discontinuation. An autopsy was performed and the diagnosis of invasive pulmonary aspergillosis was confirmed. Figure 1. Chest X-ray showing that the fungus has invaded the lung tissue. There is a large cavity in the upper left lobe of the lung, with a fungus ball within the cavity. © Lydyard, Peter; Cole, Michael; Holton, John; Irving, Will; Porakishvili, Nino; Venkatesan, Pradhib; Ward, Kate, Jan 01, 20 Garland Science, Hoboken, ISBN: 9780203856871
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
leading to the establishment of a rigid cell wall. Glycosyltransferases bound to the membrane by a glycosylphosphatidyl inositol (GPI) anchor play a major role in the biosynthesis of the cell wall. Fungal cell composition affects its virulence and susceptibility to immune responses.
Image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern