Coast Antimicrobial Review 2011

Coast Antimicrobial Review 2011 - Consensus Antimicrobial...

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Consensus Antimicrobial Spectrum Tool (CoAST) For teaching purposes only. Organism susceptibilities may vary by geographic region and clinical scenario. Therapy should be guided by results of microbiological cultures whenever possible. Patient-specific factors and clinical evidence/experience must be considered in choice of therapy (e.g. site of infection, patient immune status). Antibacterials Gram-positive Gram-negative Anaerobes Drug Strep pyogenes (Group A Strep) S. pneumoniae 1 (PCN-S or -I) (PCN-R) Staph aureus (MSSA) 2 (MRSA) Enterooccus faecalis 3 Enterococcus faecium 3 Listeria H. influenzae Neisseria spp. Proteus spp. E. coli 4 Klebsiella Citrobacter Acinetobacter Pseudomonas aeruginosa Enterobacter cloacae Serratia B. fragilis Clostridium spp (Gram-positive anaerobes) Clostridium difficile Atypicals 7 Penicillins Penicillin G +++ +++ -- -- 6 X ++ -- +++ X ++ X X X X X X X -- ++ -- X Amp/amoxicillin +++ +++ + -- 6 X +++ -- +++ ++ 7 ++ ++ -- X -- X X X -- +++ -- X Piperacillin +++ ++ -- -- 6 X ++ -- +++ ++ 7 ++ ++ ++ ++ -- -- ++ ++ + +++ -- X Naf/Dicloxacillin +++ ++ -- +++ X -- -- -- X -- X X X X X X X X X -- X Amox/clav +++ +++ + +++ X +++ -- +++ +++ ++ ++ ++ ++ -- X X X ++ +++ -- X Pip/tazo +++ +++ -- +++ X ++ -- +++ +++ ++ +++ +++ +++ ++ + ++ ++ +++ +++ -- X Cephalosporins Cefazolin +++ ++ -- +++ X X X X -- -- ++ ++ ++ X X X X X ++ X X Cefuroxime ++ ++ -- ++ X X X X +++ ++ +++ +++ +++ X X X X X ++ X X Cefotetan/Cefoxitin ++ ++ -- ++ X X X X ++ ++ +++ +++ +++ X X X X ++ +++ X X Ceftriaxone/Cefotax +++ +++ ++ +++ X X X X +++ +++ +++ +++ +++ + -- X + X ++ X X Ceftazidime ++ ++ -- + X X X X +++ ++ +++ +++ +++ ++ + ++ ++ X ++ X X Cefepime +++ +++ + +++ X X X X +++ +++ +++ +++ +++ +++ + ++ ++ X ++ X X Imi/Meropenem +++ +++ + +++ X ++ -- ++ +++ +++ +++ +++ +++ +++ ++ ++ +++ +++ +++ -- X Aztreonam X X X X X X X X +++ +++ +++ +++ +++ ++ + ++ ++ X X -- X FQs Ciprofloxacin +++ + + + -- + 8 -- -- +++ ++ +++ ++ +++ +++ + ++ ++ X ++ -- ++ Levofloxacin +++ +++ +++ ++ + + 8 -- -- +++ ++ +++ ++ +++ +++ + ++ ++ X ++ -- +++ Moxi/gati +++ +++ +++ ++ + + 8 -- -- +++ ++ +++ ++ +++ ++ -- -- ++ ++ +++ -- +++ Macs Erythromycin ++ ++ -- ++ -- X X -- X + X X X X X X X X ++ X +++ Azithro/clarithro ++ ++ -- ++ -- X X -- +++ ++ X +/X +/X X X X X X ++ X +++ Telithromycin +++ +++ ++ ++ -- X X -- ++ ++ -- -- -- -- X X X X ++ X +++ Tets Doxycycline +/- +++ ++ +++ + + + -- +++ -- -- -- -- -- + -- + X + -- +++ Tigecycline +++ +++ ++ +++ +++ ++ ++ -- +++ +++ + +++ +++ ++ ++ -- ++ +++ +++ -- +++ AGs Gent/tobra -- 9 -- 9 -- 9 -- 9 -- 9 -- 9 -- 9 -- 9 + ++ +++ +++ +++ +++ ++ ++ +++ X X X X Amikacin -- -- -- -- -- -- -- -- + ++ +++ +++ +++ +++ +++ +++ +++ X X X X Misecellaneous TMP/SMX +/- + -- +++ ++ X X ++ ++ --- ++ ++ ++ ++ -- X ++ X ++ X X Clindamycin ++ ++ + +++ + X X -- X X X X X X X X X ++ +++ -- + Metronidazole X X X X X X X X X X X X X X X X X +++ +++ +++ X Linezolid +++ +++ +++ +++ +++ +++ +++ -- X X X X X X X X X X X +++ -- ++ Synercid (Q/D) +++ +++ +++ +++ +++ X +++ -- X X X X X X X X X X X +++ -- X Daptomycin +++ +++ +++ +++ +++ +++ +++ --
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This note was uploaded on 09/14/2011 for the course PHARM mb taught by Professor Staff during the Spring '11 term at UCSD.

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Coast Antimicrobial Review 2011 - Consensus Antimicrobial...

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