Lecture 01 - Micro Introduction

Lecture 01 Micro - Lecture 01 Micro Introduction MI-13 Introduction to Microbiology The student should be able to MI-13a Distinguish between

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Lecture 01 – Micro Introduction MI-13. Introduction to Microbiology. The student should be able to: MI-13a. Distinguish between bacteria, fungi, virus and parasites (both protozoa and helminths) based on type of cell (prokaryotic or eukaryotic), relative size, genetic material, structure and replication Cell type Relative Size Genetic Material Structure (Outer structure) (mitochondria) (Ribosome) Replication Virus None Smallest (1) RNA or DNA *not both* - Protein capsid +/- envelope - None - None Requires host cell Bacteria Prokaryotic Second smallest (100) RNA & DNA - Rigid Wall Peptidoglyca n - None - 70s (smaller) Binary Fission BORDER Fungi Eukaryotic Middle (250) RNA & DNA - Rigid Wall Chitin - Yes - 80s Budding or mitosis Parasites - P r o t o z o a - H el m i n t h s Eukaryotic A lot like us -- bigger! (1,250) RNA & DNA - Flexible membrane - Yes - 80s Mitosis *membrane bound organelles: peroxisome, hydrogenosome MI-13b. Compare and contrast prokaryotic and eukaryotic cells regarding cell structure, nature of outer surface, structure of ribosomes, presence of membrane-bound organelles (such as mitochondria) and chromosome number Property Eukaryote (humans) Prokaryote ***key for antibiotics Nuclear membrane Yes No Organelles (Mito, Lysosomes) Bound Unbound - lysosome in our eyes (tears) help break down bacteria Digestive vacuoles Yes No Chromosomes Multiple Single - antibiotics: (DNA gyrase) ciprofloxacin, nitrofurantoin Membrane sterols Yes No - Peptidoglycan in membrane No Yes - antibiotics: (peptidoglycan) penicillins, cephalosporins Ribosome 80s 70s - yeast also has 80s that can cause infections - antibiotics: (aminoglycosides, macrolides) gentamicin, azithromycin MI-13c. Describe the general features of bacterial structure, including size relative to human cells, shape (coccus, bacillus, spirochete) and staining properties (gram positive versus gram-negative, acid-fast versus non-acid-fast)
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Peptidoglycan Cytoplasmic Membrane Size relative to human cells: Shapes: - Coccus – round - Bacilllus – Rods - Spirochete Staining Properties - Help ID bacteria based on color and shape (negative and positive) - Gram positive: remain purple because thick peptidoglycan prevents decolorization o thick peptidoglycan (barrier to lipid solvents so they do not decolorize and remain purple)
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This note was uploaded on 09/14/2011 for the course PHARM mb taught by Professor Staff during the Spring '11 term at UCSD.

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Lecture 01 Micro - Lecture 01 Micro Introduction MI-13 Introduction to Microbiology The student should be able to MI-13a Distinguish between

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