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Lecture 07 - Anaerobic Infections

Lecture 07 - Anaerobic Infections - Lecture 07 Anaerobic...

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Lecture 07 - A naerobic Infections MI-20a. Distinguish between strict anaerobes, facultative anaerobes and strict aerobes - Strict anaerobes o Cannot grow in oxygen o Energy source: Ferment only & Ferment and Respires - Facultative anaerobes o can grow in oxygen o grow without oxygen o Energy source: Ferment only & ferment and respires & respires only - strict aerobes o can grow in oxygen o cannot grow without oxygen o energy source: respires MI-20b. Describe the features of anaerobic organisms that explain why they are unable to grow in the presence of oxygen Principles of Anaerobic infections Infection starts in areas of poor tissue perfusion and/or injury leading to low oxygen levels . This sets up the local environmental condition that favors anaerobic conditions i.e. this case à poor perfusion was bc of diabetes (complications of diabetes) The patient was set up when the infection was started Infection is often refractory to antibiotic therapy . Antibiotics are not delivered into poorly perfused tissue. The drug will not be delivered into the tissue with the poor blood supply Anaerobic infections often require surgical intervention and/or interventional radiology procedures i.e. the infection require immediate surgical infection What is the reason why the anaerobic cannot grow in oxygen? - They cannot detoxify the metabolite of oxygen that cause cellular damage - They lack the enzymes or inefficient levels of these enzymes to reduce (listed) - Can detox à toxic agent builds up à to cell death - When exposed to oxygen will commit suicide - The aerobe due to oxygen forms many toxic products - Can cause a lot of damage to enzyme and DNA (they have to be removed) Host defense against anaerobes Major defense is normal, oxygenated tissue Because anaerobe can’t grow in oxygenated tissue this is powerful, natural defense Secondary defense is oxidative burst of phagocytes Phagocytes are able to kill the anaerobic bacteria very efficient But really the primary defense is the first prinicple i.e. (cancer patient, chemotherapy, bone marrow transplant patients) à
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