Lecture 09 - Vector-borne Bacterial Diseases

Lecture 09 - Vector-borne Bacterial Diseases - Lecture 09...

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Lecture 09 - Vector-borne Bacterial Diseases: Rickettsiae, Bartonellae, and Borrelliae. A Vector is anything that takes anything through space and time This lecture will focus on arthropods vectors Rickettsial Family and related bacteria ( small organism ): Rickettsia spp . Ehrlichia spp . Orientia tsutsugamushi Coxiella burnetti **the first four is intracellular Bartonella spp. The TRIAD – hallmarks of the Ricketsial disease FEVER Un-differential fever HEADACHE RASH (or not?) MI-25a. Describe the differences between Rickettsiae and conventional gram-negative bacteria MI-25b. Describe the epidemiology/geography, pathogenesis (with a focus on endothelial cells) and clinical manifestations of rickettsial diseases, including being able to contrast the vectors and reservoirs of typhus, Rocky Mountain Spotted Fever, and Q-fever MI-25c. List the major grouping and clinically most important species of Rickettsiae that cause the above diseases MI-25d. Describe the approaches available for the laboratory diagnosis of Rickettsial infections Rickettsiae Gram negative , very tiny coccibasilli Only grows inside the cell Do not have cell wall (penicilin will not work against any of these (unlike the other gram negatives) Spotted fever group Rickettsia rickettsiae , cause of Rocky Mountain Spotted Fever Transmitted by Dermacentor spp. Ticks (dog ticks— different rickettsia is transmitted by the different vector) Can be aerosolized Recent report (NEJM 2005 Aug 11;353(6):587- 94), Rhipicephalus (still a tick) Potential BT agent--BSL3 conditions for study (since it can be aerosolized) Serologically differentiated from typhus group Rickettsiae by LPS reactivity on IFA (indirect fluorescent assay) You grow the organism and light it up with a serum Different antigen between the two groups light up infected cells certain dilution of the serum positive Typhus group Rickettsia prowazeckii , cause of epidemic typhus killed more people in WWI than hostilities Transmitted by human body louse i.e. the head lice doesn’t transmit anything, but the body lice does Rickettsia typhi , cause of endemic or murine typhus Transmitted by rat and cat fleas; rat, opossum reservoirs; seen on CA-TX/Mexico border, Hawaii Can be very sick, fever liver test, severe lung disorders 100s of vectors ; different ticks or lice or fleas worldwide distribution of epidemic typhus found in poverty around the world geographically restricted vector restricted infected patients Vasculitis with the end arterioles being most affected ; People can get gangrenous and die of septic shock can also lie dormant for decades after treatment and manifest to Rickettsia Prowazaki
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This note was uploaded on 09/14/2011 for the course PHARM mb taught by Professor Staff during the Spring '11 term at UCSD.

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Lecture 09 - Vector-borne Bacterial Diseases - Lecture 09...

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