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Unformatted text preview: Lecture 18 - HSV and VZV. MI-39a. Describe the characteristics, structure and classification of the herpes virus All herpes virus has: [rarely cause disease]- Envelope (which acquire lipid membrane from their host)- Isoahedral capsids- Tegument – amorphous protein-filled region of the envelope and capsid o viral encoded protein between the capsid and envelope o alpha-TIF –transactivator of the HSV alpha genes o viral host shutoff (VHS) protein – promote the degradation of host mRNAs o These are transactivator – that are expressed in temporal order cascade- linear double stranded DNA genomes o Remember there is no spare genome space!- Genomes made of UL and US regions bounded by inverted repearts (IR) o exact arrangement differ among the viruses o HSV: TR-UL-IRIR-US-TR o VZV: -UL-IR-US-IR- Virus replication and assembly = NUCLEUS of the infected cell (last step in virion assembly is in the cytoplasm) o through nuclear pores- There are no common Human Herpesvirus Family antigens- All members can establish latency in their natural host Classification: (based on their biologic properities and genome organization) Class Host Range Replication Lab Infects alpha herpesviruses HSV VZV Broad Short cycle CPE in cell cultures - eosinophilic intranuclear inclusion bodies- multinucleated giant cells- subsequent cell death Latent infections Sensory Neurons beta herpesviruses Restricted Long cycle Slowly progress in cell culture (CPE characteriezed)- cell enlargement (cytomegalia) Presistent OR Latent infections...
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This note was uploaded on 09/14/2011 for the course PHARM mb taught by Professor Staff during the Spring '11 term at UCSD.
- Spring '11