psych106-4

psych106-4 - LECTURE 4 SYNAPSES AND DRUGS January 13th...

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L ECTURE 4: S YNAPSES AND D RUGS January 13th
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L ECTURE O UTLINE 1) Ion Channels Voltage-, Stimulus-, and Neurotransmitter-gated 2) Types of NTs 3) The Process of NT Synthesis, Storage, and Action 4) Types of NT-gated receptors 5) Synapses and Drugs
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C ONTROL OF I ON C HANNELS Voltage-gated : open/close in response to membrane potential changes “Stimulus-gated” : channels pertinent to the Senses NT-gated : chemical, today’s lecture
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T YPES OF NT S Amino Acids (NH 2 + Acid): glutamate, GABA, glycine, aspartate Acetylcholine : similar to AAs, but NCH 3 instead of NH 2 Memory/memory deficits, muscular control, attention Monoamines : Indoleamines: Serotonin (Mood, sleep, appetite regulation) Catecholamines: Dopamine (reward, prediction of reward, motivation, pain) Epinephrine (sympathetic nervous system, heart rate, respiration) Norepinephrine (sympathetic nervous system, arterial blood pressure)
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T YPES OF NT S C ONTINUTED Neuropeptides (two or more AAs) : endorphins (pleasure), Substance P, many others Purines : ATP, adenosine, many others Gases : Nitric Oxide (blood vessel dilation)
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W HERE DO NT S COME FROM ? Acetylcholine (Ach) Catecholamines Serotonin (5-ht) Choline (Dietary) + Acetyl Coenzyme A Acetylcholine (Ach) Phenylalanine (dietary) Tyrosine Dopa Dopamine Norepinephrine epinephrine Tryptophan 5-htp Serotonin (5-ht)
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The neurotransmitter needs to GO AWAY!
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W HERE DOES THE NT GO ?
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psych106-4 - LECTURE 4 SYNAPSES AND DRUGS January 13th...

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