psych106-19 - Lecture 19(March 8th Learning and Memory...

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Lecture 19 (March 8th): Learning and Memory: Neural Mechanisms Lecture Outline 1) Hebbian Mechanisms explain Associative Learning 2) Neural Underpinnings of Hebbian Mechanisms Long-Term Potentiation, LTP and Long-Term Depression, LTD 3) Examples of Hebbian Mechanisms in Visual Cortex (via an “LTP-like” mechanism) 4) Relationship between LTP and Learning/Memory Behavior 5) Non-Associative Neural Mechanisms e.g., Habituation (Aplysia), You can SKIP Sensitization
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Learning = Memory and, whenever we learn something, the BRAIN must be changing! Donald Hebb : Associative Learning must be a change at the synapse Hebbian Mechanism: Increase in synaptic strength (i.e., connectivity) between a PRE- and POST- synaptic neuron when the two neurons are active simultaneously. Or…. “Neurons that fire together get wired together”!
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“Neurons that fire together get wired together”! CR Training Let’s revisit Classical Conditioning which is a This is an Implicit memory association, but this kind of phenomenon would happen for Explicit memory associations too!
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Demonstrating Hebbian Mechanisms in Neurons in vitro (i.e., in a dish) 1) Measure “baseline” POST-synaptic response to single pulse onto axons of PRE-synaptic neurons.
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