Lecture 10 - Organization of bone Composition of bone...

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Organization of bone
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Composition of bone Connective tissue Extracellular Matrix Cells Fibers Ground Substance Osteogenic cells Osteoblasts Osteocytes Osteoclasts Collagen Fibers Contains organic and inorganic components (Noncollagenous proteins)
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Extracellular matrix • Organic components (secreted by osteoblasts) – Ground substance (glycosaminoglycans – GAG) • Glycoproteins = polysaccharide + protein – Chondroitin sulfate and Hyaluronic acid • Negatively charged – trap water – Collagen fibers (type I) • Fibrous protein arranged in helical form • Very resistant to pulling forces • Provides flexibility and a framework for deposition of calcium crystals
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T. A. Einhorn, Bone metabolism and metabolic bone disease. In Orthopaedic Knowledge Update 4 Home Study Syllabus (J. W. Frymoyer, ed.). Am Acad Orthop Surg., Rosemont, 69–88 (1994). Type I Collagen
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Extracellular matrix • Inorganic components – Water • Attracted to ground substance • Makes up 25% of the extracellular matrix – Hydroxyapatite Ca
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Lecture 10 - Organization of bone Composition of bone...

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