Lecture 19 - Cellular Basis of Muscle Contraction...

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Cellular Basis of Muscle Contraction
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Sarcomeres: Functional Unit of Contraction Elements of Sarcomere Structure 1. Thin Filament Attached to Z line (Z disc) Z ‘myosin binding site’ on actin covered by regulatory proteins composed of two helically arranged strands of actin two twisted strands of pearls
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Sarcomeres: Functional Unit of Contraction Elements of Sarcomere Structure 2. Thick Filament ‘myosin head’ has ATPase activity when bound to actin imagine two golf clubs with their handles twisted about each other spans the distance and overlaps thin filaments Z composed of a highly organized array of myosin molecules
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Contractile Proteins 1) Actin found in thin filaments has myosin binding sites for crossbridge formation with myosin 2) Myosin found in thick filaments has myosin head that binds to the myosin binding site on actin and forms crossbridge during muscle contraction
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Regulatory Proteins 1) Tropomyosin found in thin filaments covers the myosin binding sites on actin when
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Lecture 19 - Cellular Basis of Muscle Contraction...

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