Lecture 21

Lecture 21 - Muscle Energetics The immediate source of...

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Muscle Energetics
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The immediate source of energy to support development of tension: ATP 1. Hydrolysis by the myosin head group fuels tension generation 2. Hydrolysis by the Ca-pump of the SR supports relaxation
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Where does the ATP come from? ATP is not ‘stored’ only enough to support ~2 sec of maximal force 1. Cell ‘pool’ of ATP
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Where does the ATP come from? 2. Creatine Phosphate (CP) pool CP stores ‘high energy phosphate’ the CP ‘pool’ has enough high energy phosphate to support ~15 sec of maximal contraction CPK CPK creatine phosphokinase (CPK)
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Creatine Phosphate Pool After a meal, ATP + C b ADP + CP During exercise, ADP + CP b ATP + C
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Creatine •Creatine is a small amino acid-like molecule that is synthesized in the liver, kidney and pancreas and transported to muscle fibers •In a relaxed muscle fiber creatine is 3-6 times more plentiful than ATP
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3. Glycogen (used
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This note was uploaded on 09/11/2011 for the course PSIO 201 taught by Professor Stanescu during the Summer '08 term at Arizona.

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Lecture 21 - Muscle Energetics The immediate source of...

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