Lecture 24

Lecture 24 - Cardiac and Smooth Muscle All types of muscle...

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All types of muscle (skeletal, cardiac and smooth) generate tension The underlying mechanisms in all three rely on variations of two common themes 2. Regulation of cytoplasmic [Ca 2+ ] Cardiac and Smooth Muscle
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Cardiac Muscle 1. Function: what does heart muscle do? Pumps Blood involves contraction of muscle around a confined volume, increasing the pressure so the fluid can be pushed through the circulatory system
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Cardiac Muscle 2. Structural Features (compared to skeletal muscle) a. Smaller cells (branched) b. Less extensive T-tubule and SR system c. Myofibrils organized into sarcomeres d. Extensive cell-to-cell interactions Intercalated Discs containing Gap Junctions & Desmosomes
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Microscopic Anatomy of Cardiac Muscle
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Cardiac Muscle 3. Functional Issues the Sliding Filament Model still applies. .. Crossbridge cycling Ca 2+ interaction with thin filament regulatory proteins Similarities (to skeletal muscle)
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Cardiac Muscle 3. Functional Issues Differences
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Lecture 24 - Cardiac and Smooth Muscle All types of muscle...

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