Lecture1 - MCB 110L Lecture 1 01/19/2011 Prof. Qing Zhong...

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MCB 110L Lecture 1 01/19/2011 Prof. Qing Zhong 306 Barker Hall
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Cell division in Drosophila embryo Mitotic spindle pulls chromosomes apart during mitosis. Microtubule movement is mediated by motor proteins.
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Microtubule instability Microtubule directs the movement of chromosomes and organelles by polymerization and depolymerization and motor proteins.
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Three classes of dynamic microtubules Green-microtubule Red-kinetochore
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Filament polymerization and depolymerization can do mechanical work Basic types of microtubule force generation. a Pushing, b pulling; c , d sliding. a , b The organelle ( orange ) is bound to the microtubule ( green ) by a fixed link ( red ). a The organelle is being pushed away from the cell edge by a microtubule polymerization force. The microtubule polymerizes by addition of new subunits ( light green discs ) at its end ( arrows ). b A depolymerizing microtubule, which is connected to the cell edge by an active motor ( dark grey ), is pulling the organelle towards the cell edge. Depolymerization is accompanied by a loss of old subunits (
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Lecture1 - MCB 110L Lecture 1 01/19/2011 Prof. Qing Zhong...

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