Lecture11 - MCB 110L Spring 2011 Lecture 11 2/23/2011 Prof....

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MCB 110L Spring 2011 Lecture 11 2/23/2011 Prof. Qing Zhong
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How to write a scientifc proposal? • Defne an important question • Gather inFormation and observe • ±orm a hypothesis • Preliminary study • Analyze data, Interpret data and draw conclusions • Discussion • ±uture study http://en.wikipedia.org/wiki/Scientifc_method
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Proposal Format is that of paper published in journal. Basic outline Title Authors Abstract Introduction Results Discussion Future experiments References Tables with legends Figures with legends
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Resources • Start here Lab Guidelines • Web resources: http://www. nmas . org/JAhowto .html http://en. wikipedia . org/wiki/Scientifc_method http://en. wikipedia . org/wiki/Scientifc_paper
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TITLE — be concise and yet specifc; a title is a mini- abstract that distills the essential fnding oF the paper. “Bidirectional transport oF amino acids regulates mTOR and autophagy” AUTHORS — list oF persons who contributed signifcantly to the paper; this becomes your Formal scientifc name that will stick with you to eternity. ( )
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Abstract ABSTRACT — concise summary of paper, ~200 words. [1] System studied [2] Objectives of the study [3] Major results obtained (how they were obtained) [4] SigniFcance of the results Smac mimetics induce apoptosis synergistically with TNF-alpha by triggering the formation of a caspase-8-activating complex containing receptor interacting protein kinase-1 (RIPK1). Caspase inhibitors block this form of apoptosis in many types of cells. However, in several other cell lines, caspase inhibitors switch the apoptotic response to necrosis. A genome wide siRNA screen revealed another member of the RIP kinase family, RIP3, to be required for necrosis. The expression of RIP3 in different cell lines correlates with their responsiveness to necrosis induction. The kinase activity of RIP3 is essential for necrosis execution. Upon induction of necrosis, RIP3 is recruited to RIPK1 to form a necrosis-
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Lecture11 - MCB 110L Spring 2011 Lecture 11 2/23/2011 Prof....

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