MCB110L_lecture19

MCB110L_lecture19 - MCB110L Lecture 19 Andreas Martin Outline Microarrays Solexa sequencing(remaining slides from lecture 18 and following new

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MCB110L Lecture 19 03/30/11 Andreas Martin
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Outline: Microarrays Solexa sequencing (remaining slides from lecture 18 (03/18/11) and following new slides) Outlook: Lecture 20 (04/01/11) Protein stability, stability assays, enzyme catalysis Lecture 21 (04/06/11) Protein structure, structure determination by X-ray crystallography
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Protein structure Primary structure (1D) Amino acid sequence. Secondary structure (2D) Alpha helices, beta sheets, turns, omega loops. 2D arrangement of amino acids in specific conformations, hydrogen bonding mainly defines these topologies. Tertiary structure (3D) 3D structure of a single polypeptide chain Packing of 2D elements usually mediated by hydrophobic interactions. Quaternary structure (4D) assembly of multiple chains / proteins predictions based on primary structure: - secondary structure relatively reliable (65-70% probability) - tertiary structure still very difficult, no quantum mechanical calculations (systems too big)
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This note was uploaded on 09/12/2011 for the course MCB 120L taught by Professor Fairclough during the Spring '08 term at UC Davis.

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MCB110L_lecture19 - MCB110L Lecture 19 Andreas Martin Outline Microarrays Solexa sequencing(remaining slides from lecture 18 and following new

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