MCB1_2 - MCB 110 course policy, lecture slides, practice...

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MCB 110 course policy, lecture slides, practice questions, previous exams, and answer keys are and will continue to be available on the course website: https://bspace.berkeley.edu PLEASE READ the course material posted on the course website. There are two evening midterms and a final exam, all closed-book, each specific to one third of the course (each worth 33.3% of your grade). Discussion sections are optional but highly recommended. You may attend any section even if you are not enrolled for it, as long as all of the sections remain small enough for teaching effectiveness. Sections begin next week. Part I (of III) by Prof. Collins Office hours Friday 11:30-1:00 in 331 LSA Email kcollins@berkeley.edu
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A word about what to learn and what not to memorize: You will NOT be expected to draw anything complex from memory (like a specific molecular structure or details of a chemical pathway). You WILL be asked to apply understanding of the material to new problems. Exams are not trivia contests, but details can be important. What you should master will be indicated by descriptions of material DURING CLASS.
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Nucleotide units: Sugar, base, and phosphate sugar phosphate (mono, di, or tri) base RNA: 2’ OH DNA 1
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Canonical bases in DNA and RNA RNA only DNA only Additional base structures are created by enzymatic modification, but this occurs after nucleic acid synthesis using the canonical nucleotides. 2
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chemically reactive phosphodiester linkage & glycosidic bond Important features of a polynucleotide chain backbone has negative charge bases have hydrogen bond acceptors and donors the chain has polarity: 5’-3’ 3
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Watson-Crick model for DNA structure 3. Duplex (ds) strands
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MCB1_2 - MCB 110 course policy, lecture slides, practice...

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