SectionNotes1a - from Albert Einstein University Monday...

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from Albert Einstein University Monday, January 24, 2011
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1’ 2’ 3’ 4’ 5’ 1’ 2’ 3’ 4’ A D A M N N O CH 3 Looking into the major groove Dotted line indicates H-bond between Adenine and Thymine. Atoms are colored by element identity. Other than the AT base pair indicated here, bases are represented as simple rings without functional groups shown. Major groove allows access to sequence information that can differentiate AT from TA and GC from CG. More sequence information in the major groove than the minor groove. Adenine Thymine D M A H H-bond acceptor H-bond donor Methyl group Monday, January 24, 2011
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2’ up 2’ down B-DNA A-DNA ( and RNA ) from Tulane University 3’ up A-form RNA has the 3’ carbon pulled up out of the plane of the rest of the sugar ring. In B-DNA the 2’ carbon is pulled up. part of
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