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Unformatted text preview: Important Note: TdT (terminal deoxynucleotidyl transferase) adds nucleotides randomly to the ends of the segments to be ligated. This provides junctional diversity. After the random nucleotides have been added the ends are joined by NHEJ (non-homologous end joining). Figure adapted from Reddy et al. V(D)J Recombination: Born to be Wild. 2010. Seminars in Cancer Biology 20: 254-260....
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This document was uploaded on 09/12/2011.
- Spring '09