BISC220-Exam 3

BISC220-Exam 3 - Name ED Number Third 50 minute Examination...

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Unformatted text preview: Name ED Number Third 50 minute Examination BISC 220 Spring 2010 09 April 2010 Instructions for filling in the Blue Seantron Answer Sheet: 1. _ Enter your name in the NAIVIE field (your last name first), and fill in the appropriate bubbles. 2. Enter your USC STUDENT ID NUMBER in the field labeled IDENTIFICATION NUMBER, and fill in the bubbles. 3. Circle your TA’s name in this table and enter hisfher code in 0&P columns in the SPECIAL CODES field and fill in the bubbles. 'First’name Last name TA’s Code Manse} Bruno 00 Yang- -Ho (David) Chen“WWWuw @3511 g Wm“ _ . YoungKYOung " Kim. Jessica .. Ledesma 04 Melissa Madison 05 Yunxiang Mu 4— O6 Nimna Ranatunga 0? J Melissa Romero 08 Yukai 4. Bubble in your answers to questions 1— 14 with a pencil on SIDE I. Be sure to fill in the entire circle. Fully erase all mistakes. 5. ONLY exams written in PEN can be submitted for a re-grade. If you make a mistake .do notuse White-out, just cross it out. _When you are done turn in the entire exam with the Blue Scantron Answer Sheet to your TA- I Scantron Score I 5'; f 70 pts Page #3 I g I 8 pts "Page #4 3 f 13 pts Page #5 I") f 10 pts Page #6 iii / 20 ots "EQQWIEW? pts Page #8 _[0_l 13 pts W Name ID Number— _ EXAM 3 —— BISC 220 — Spring 2010 April 9, 2010 ' This exam has 26 questions on 8 pages. Be sure you have a complete copy. Write your name and USC 11) number at the top of each page. Please read each question carefully, and be sure you understand what is being asked. Questions 1-14 are worth 5 points each should be answered on the provided scantron sheet. Point values for questions 15—26 are indicated. Answer questions 15-26 in the spaces indicated. Material written outside these spaces will not be graded. 1. When a persorl who has been lying horizontally moves to a standing position, which one of the following compensatory changes would be expected to occur? a. bradycardia d. vasodilation in systemic arterioles b. decreased cardiac output e. increased strength of cardiac muscle contraction . c. vasodilation in systemic veins 2. Which one of the following drugs would likely help a patient suffering from hypertension (high systemic blood pressure)? a. A drug that stimulates arteriolar vasoconstriction. b. A drug that blocks receptors norepinephrine in cardiac muscle. 0. A drug that blocks receptors for acetylcholine in cardiac muscle. d. An antidiuretic drug, i.e., one that reduces the volume of urine produced in the kidneys. _ 3. Blood pressure in a capillary is 30 mm Hg at the arteriolar end and 15 mm Hg at the venular end. — The osmotic pressure exerted by plasma proteins is 21 'mm Hg. The osmotic pressure exerted by _ proteins in the extracellular space surrounding the capillary is 1 mm Hg. The hydrostatic pressure in the tissue surrounding the capillary is 0 mm Hg. The net force producing fluid movement across the capillary wall at its arteriolar end is _a. 6' mm Hg into the capillary '. _ .' L1_q0_i::--_mifl=iff—miiu b. 6 mm Hg out of the capillary . [3"— U ...... i c. 9 mm Hg out of the capillary ----------------------- - """ "fwd—"L .. d. 10 mm Hg out of the capillary ire . .. .. 18 e. 15 mm Hg out ofthe capillary ,1” u. "afiew'tfiu 4. Which one Of the following does not occur when blood passes through most systemic capillary beds? a. The pH of the blood decreases. ' _ . . .. x b. The partial pressure of 02 in the blood decreases. _ - f“ . ’ 1.5" c. The number of erythrocytes per u] of blood increases. ’: d. The hemoglobin-Oz dissociation curve shifts to the left. 6. Per unit time, the volume of blood leaving the capillary in the downstream venule is less than the volume of blood that entered the capillary from the upstream arteriole. . ... debit." 'x . 5. Which one of the following conditions would not cause a rise in the level of crythropoictin in the blood? _ a. hemorrhage c. dietary iron deficiency b. living at high altitude .d. increased blood flow to the kidneys Page 1 of 8 Name ID Number 6. An elderly female patient is suffering from severe edema in her legs. Her physician prescribes a diuretic (a drug that increases the volume of urine produced). Which one of the following is unlikely to occur in this patient while she is taking the diuretics? a. A decrease in total blood volume. 11, Decreased filtration of fluid from capillaries in her legs. c. A decrease in concentration of proteins in the plasma. (1. Increased reabsorption of fluid into capillaries in her legs. 7. Within normal human blood a. most of the C02 is bound to amino groups on hemoglobin. 4b? the eosinophil is the most common type of leukocyte. c. myeloid stem cells differentiate into erythrocytes. d. there are more neutrophils than lymphocytes. .97 there are more leukocytes than erythrdcytes. 8. The return of lymphatic fluid from the foot to the heart would be. ,6" decreased by exercise. b increased by massaging the font. c. decreased if valves in leg veins were incompetent. .1. decreased if capillary permeability in the foot were increased. [efincreased when a person lying on his back rose to a standing position. 9. Which one of the following is not a function served by plasma proteins? a. tranSporting Oz in the blood K lysis of antibody-tagged cells 1. reabsorption of fluid into capillaries ,df transporting certain hormones in the blood e. contributing to the pH buffering capacity of the blood 10. Which one of the following is reaponsible for the movement of Oz horn alveolar air into pulmonary capillaries? a. filtration (1. primary active transport b. passive diffusiOn e. secondary active transport 0. facilitated diffusion ' ll. Imagine a person who is hyperventilating, i.e., breathing faster and deeper than is necessary to meet the body’s needs. Which one of the Following statements about hyperventilation is correct? Q; Hyperventilation lowers the pH of the blood. 36'. Hyperventilation increases the saturation of the blood with 02. ,c’. Hyperventilation raises the concentration of C02 in alveolar air. d.‘ Within erythrocytes, hyperventilation tends to lower the affinity of hemoglobin for 02. c. Hyperventilation reduces the excitatory outflow from the brain stem respiratory center to the ' diaphragm muscle. Page 2 of 8 4 pts. 4 pts. Name ID Number 12. If a person with pulmonary edema has an alveolar P02 of 100 mm Hg and an alveolar P502 of 40 mm Hg, which one of the following sets of arterial blood gas values is most likely to occur? .6.me 7-105 mm Hg, P002 = 35 mm Hg C b. P0; = 100 mm Hg, P002 2 40 mm Hg ‘ c. P02 = 90 mm Hg, Pcoz = 45 mm Hg 13. The fluid most likely to contain high levels of immunoglObulin A is a. Whole blood d. intracellular fluid . b. plasma e. saliva ' c. lymphatic fluid ' 14. Which one of the following statements about infiannnation is false? a. Histamine released from mast cells causes relaxation of smooth muscle in the walls of capillaries, which increases local blood flow. b. Delivery of oxygen and nutrients is aided by'increased fluid flow through inflamed areas. 0. During inflammation, plasma proteins leak into the extravascular space, increasing the rate at which water leaves capillaries by osmosis. d. Neutrophils accumulate in the extravascular space in inflamed areas. e. Both basophils and mast cells are granulocytes. ---- Answer the remaining questions (15-26) in the spaces provided on these sheets. m- 15. Indicate whether each of the following statements is true or false by writing the word “True” or “False” in the blank. Do not write Tor F. a he a. All veins in the body have a bluish color, indicating that they contain partly deoxygenated blood. _ Zr W4 ..b Immediately following atrial systole, the AV node delays ventricular systole long enough ' to allow the atria to empty their blood into the ventricles. thQ o. During ventricular diastole, blood pressure in the aorta is lower than blood pressure in the pulmonary artery. _MAH types of blood vessels except capillaries contain smooth muscle in their walls. 16. Indicate whether each of the following statements is true or false by writing the word “T rue” or “False” in the blank. Do not write Tor F. {r or. a. Activated helper T-cells stimulate cytotoxic Twcells by secretion of cytokines. jit v.52. '13. Plasma membranes of macrophages contain both class I and class II MHC proteins. Rig 2. c. Macrophages secrete cytokines that directly activate cytotoxic T-cells. Euiia d. CD8— —positive cells bind to antigens presented by class ll MHC proteins E“ a e. Plasma membrane receptors on T- -lymphocytes are composed of identical pairs of heavy and light chains. Page 3 of S Name ID Number 4 pts. 17.1n5piration is mainly due to contraction of the (jig Flu main : {I and éfiWn/Mfit es i-r—«l *1” muscles. 18. One of the complications of rheumatic fever, which is caused by a streptococcal infection, is mitral stenosis, a permanent narrowing of the opening of the mitral valve (left atrioventricular valve) of the heart. This condition increases the resistance of the valve .to blood flow and causes the valve to be incompetent, i.e., it cannot close completely at the appmpriate time. Imagine a middle-aged patient with mitral stenosis, but no other cardiovascular or respiratory disease. What changes, if any, would you expect in the following parameters, compared to a healthy person without mitral stenosis? Briefly explain each answer. a. pulmonary blood pressure . 3. x Ill“: ?ul1~x£}<‘\e~{ y like-150k pré.s£c=v"‘5' riM‘i to like im we: as? "A ”P"- ““5“ ‘ U? 7 n < man‘x valve. llh’i "‘ESW‘LRM“? / (-30,th Foam We pulmmtlryrtitmil‘ (UL-031 “WHY“? ‘f’hli’btlacwxl, iokaitl ?NS£vx-t“€'. b. P02 in systemic arteries ' . . . . . ’fl {’ ks g-f sin-pm Ct. (“Adam-N gi‘yuhi ‘w \ :2. IL;- ‘ \ {1:2 I ‘ Hag {of} (in 'ifiai‘f an ’ (fit (.2 Xys in 11:] HI? ‘ (cg? 6 Rice 6): . 2” Hr - 4": W‘pefc‘ TWA {‘11,- Chm-l The -’ - .. ‘ mi vs 6 ‘1 a =14" fifth“? . e 6'1“? (. ‘l'é LG . {flawl‘t {(2‘)th lyre.“ Hal NJ . we riffi;:;":i::ti_ifii;x c. rate and depth of breathing movements Ram (and Chlaf'fi“ c4 bitctw'tnri lvxoc-eone....r’n; have agitated 20,, we all a; stow-l» mg! “m m P“. seesaw, Shani “UM as (A tY.SL~l"l"' as} (\n ..‘n(_-,.,.M?E_R,1_u “kw!“ ““9”?“ {9-le Le“£’L 5"” C" {fit‘h-L‘W‘ ”‘3. d: é“; ”t “he blew}; E. latch immigi {flock “to chw: recry‘Al—t’ 6" "It”? ACLEFHI (:4 ion ‘er 'f‘itn<_ MW WW5“ “2 Page 4 of 8 Name ID Number 10 PtS- 19. a) How would you expect blood pressure in the pulmonary arteries to compare with blood pressure - in the aorta? Explain your answer. Obttioci ‘réSSo‘rfi m “WI-é. A elf-Vines l5 ' lt-ét‘. i'fihcwp {mic/veg ‘{~‘\"3-$ 5 W W1 in R/ {5.x moan; ‘j .. '_ . . . '3": 'k’t\.8 (5&0 («'6‘ x g‘LU‘GCl (J C '»'\c} W W. L-LLJM JVivLQ (LL); M m M K‘\' M Ckkk ‘21" ¢nhifil tar-1117 'iY‘x LKL-ujh‘ { {15 m EWLV‘ , . ‘ 5‘ 1 \yéwtw him} wuss-are {'0 (watch 1 j/A -{;/'i1_€ gyJ-MCC (.éd Lat-”ii, h): S . and: («an , T1125 N’qul.vl m” KIM-Are. HIM! art—A24“?! m (to-r hip, {\{I‘Q r": cafll “(+1.4 9] . 'T‘k E 5' in unease I .ch i Lati— I‘m-«j . ,. inbrxcxr'" r . . - _ . y HA2 ‘ V \i _ . . _ . skSiSPTni E . [Mag U V (En-s"; Wx “mi-wind J '4 Ci w/t ‘qu ubflf‘flimi‘e‘, L, we {3" *9 b) How would you expect the sum of blood flow in both pulmonary arteries to compare to blood flow in the aorta? Explain your answer The. .‘m‘fi (3+ 131m; a ”Hot”; ‘1‘“ 30:15?“ PM’K‘SWUAc-{Y (Rf War-1e"! Ska-mtg. [oi lA‘WW'L ”h” ““3 him”?! 9de “to Wake _aoi'¥cr. 2 fl.“ . -.. - .! ' ' -' w- “x '. ‘ flW-S‘i cur-hum?) ‘3‘“? “”‘Méd‘Td "" Saga, .1 r1: 9kg. Whoa m. h {$43. :73‘5‘3 5'45“" fi'vgk" MEV‘ 44%? LH’ILQ-‘fl, “fink/P Quick 131?. {a “gt-M134“ F 04C. {315i CELT.(-£ it}. e} (HI-Rf Ping {L1 :15 J at” >.>{J4&A1lr( (Ii-'1' MHZ Page 5 of 8 x. Name ID Number 6 pts. 20. For each of the 3 conditions listed in the first column, indicate whether the 4 parameters listed 1n the other columns would increase, decrease, or not change by writing I (for increase), D (for decrease , or NC for no chan e . Alveolar P02 Arterial PO; A“: R Tidal Volume Arterial Pcoz Moderate Exercise Partial Tracheal Obstruction Resting on a Hi 11 Mountain M Tidal volume IS the volume of air inhaled or exhaled during one breathing cycle without making special effort. - '6 pts. 21. Write a number or numbers in each blank so as to match each of the immunoglobulins in the left— . hand list with its appropriate functions or characteristics in the right—hand list. Each of the items in the right-hand list can be used once, more than once, or not at all. .‘ .3» 3. IgA 1. contains eight antigen binding sites Ll. b. IgD 2. antigen recognition by T lymphocytes 7» c. IgE 3. most abundant antibody in breast milk gr ‘3 (1. IgG 4. antigen recognition by B lymphocytes i\ gfgg- (7. e. IgM 5. activation of complement system -«/ St. 6. first antibody secreted by plasma cells 7'. release of histamine from mast cells 8. release of performs from natural killer cells 8 ptS. 22. Why, 1n the course of surgery to remove breast cancer, would the surgeon also want to remove some of the axillary (armpit) lymph nodes? In Sufi/39.1111? ‘l‘o N..evic-.r~e. ten {JAE}; W22. im’rje cfl bW 5d, LWWFHW a“? t’ke. {Mn-9‘35»- iyfif t‘ “5th- és‘i‘e . {ll L15! J ital l’ll FA? {1/ ‘1' H“? . L “"4: 3" {J h” M? l“ Uh {‘c h firm-u HM ha! Cue: ‘ the (t X {5ch 5. Ily “'1le iii-t l3 pa. cl (eta/L c {3' r“ H? l H I-{zdgi'i' lee-Wi- _ E; E”! 1/le [Hype-I F L‘h ft (- S ydi‘t‘m . W“ C c“- l {at M; £93”: I. “-1 a Page 6 of 8 Name ID Number 1 l _ 9 PtS- ' 23. Compare and contrast inflammation and infection. Infickmmntwn ‘3. true \etvsyuixt :L/f-xnn’te (cirque bu Mas in-Hu-v‘HE /=3y..'1i-3€.3-1 crittfl- 033’3335 .ioy (in inirethé‘n. .=' . {6.43.} ’ 1 mt 3'31' = - ii} gum: “‘5‘" W Y - J‘- (“‘3 ”d khhmt“\u'{{ ME i4 :5 3 332 We “:6“?! (3.1 h‘un Mei }M_n1i3~{_e‘3utéipar§i¢;>iv 1“th w H: 1 (“A . ' 3 3: . 3: 3- 33171- Tim! witness; {Diva-3‘ 31g..1“8.('.a-e(i' (31,1)1330-13- ftflflt’ \ ‘ ‘ y . -. - ,3, . 3 -- - ‘- . =3. (' items-13’ _= 13'»: 131323314; 3* 1133/41 grimy: hi rm rebuff-(k {fli- I 3 3 J t; if v.34 13333. ,113-33333333 =33 3 33333-33333 33 l . 1;!" 33:. H" (£99.35 fixed“ 1‘3 i165! i'fi‘ (3k "LU"? LA? L6 3 PtS- 24 Joe, a sophomore BISC 220 student volunteers 111 a research lab that studies antibodies that fight viral infections. While he was at home on the last night of Spring Break, just before returning to school, his young cousin came to visit and greeted him with a big hug. A little too late, he learned __ that the cousin had an active infection with measles virus. Joe knew he was exposed, but couldn’t flit remember if he had measles before, and was thus immune, or if he hadn’t had measles, and was E i " ' therefore likely to get sick He knew he could answer that question the next day when he returned to his research lab on campus. Describe a simple test that Joe could do 1n the immunology lab to answer his question. ' i/{mxtmwj tux feiuf‘é. \‘u an can“ (3-33-31 I .. f - q . ‘ E ., , I.‘L r1 .rx-a 1"‘(2 1' 1.1.11 ' .7 met-t; if} £33m; “he; T3293 Mtg-3:3 5-331- l 1 "W“ .t 5‘ - .31 let-vain r1? 5 L—t \ “‘3‘ t i’\ i (.31 (J 4's“. 1 '1‘1 EM t," 'M' 91" )3” {$.43 { I I h.) a b 3331-3331333; 3" 333333343333433’3 3’33‘3E ”3331333” 3 33333, bk {3 3,‘ ,1 i“ 2133.34"; ck 1" (Lou .- °\ ”1K3?“ it") h‘{ E“: f x .}fy\,\..3{\ Er’ttu-F 3’3“?!) EQQ.(,5'L.1i;‘T/{ ' ‘V\(¢U‘€— A I . ’1; 344,13 31.333333 333333‘333f3 333333333" ‘ - ' . 3 3 is L, ifie‘: 3133-35..) €fi.c...421 13’“? jifi“ 3" I 1/ . i (C 1" 3-4;: I I) L ”Mi i214 {Cr-aid (-3 $39- 639 ‘ b “I — 3' 3 II?" ‘itl 1 . f f ,3 _ 11/th f%\\( ,5 ,3 . .' _‘1, ._ 13 3 {Viv}; je‘<". 1,33 1.4;; ~ =. 3 3-3.3,3 3333333} 3333 431311 in :‘i ‘ "“5 J M 13 i 5 ‘9' “MK * 3 Page 7 of 8 8 pts. 5 pts. Name . ID Number” _ 25. Explain, in terms of the underlying mechanisms, why the allergic reaction to ragweed pollen (hayfever) takes only seconds or minutes to develop, while the allergic reaction to the toxic oil in poison oak takes hours or days to deveIOp. «Emma In to“! €".§i‘€,l{‘ji(, matinee cm ti 5.» catty .,- Sc (rail/lg 1" J at? Sew; v1 art (git an m. 5cm?!) a; 0i? i $3 {but iii-"ice f4 E" _ {kg-R4 {3W xfiitfl- 3‘ “q 3"; . I; f4 {A} Leaf} ’ I- a); 3:6) (r- . fig calibre“ {mi-“:31 Him-ml “rt- When an “ids-“'51:” ' 2 A ., . _ - Jig I r ., .1“ it ’ enraged? 57‘ fife“ 1'1"" M“: 1?" {ii-i ' “L t 5 . .1? l g“; -'._ .3- } '3.___.{¢\ k if Min Kim {E h? LYi ectJfia\/h‘5hei“'°\t’ ("nub ' J :1AL {a :w '. -,. _ 4:4 {W 2 "' “MS we. Ha.” {Ln (rifriint “tam-'3‘ “’1 J 1.0 . _, H -- ;-,mt 1‘ V/Felz y r.) {-454 .‘c. ave-sham autism_.r§.r at"; ”(M-T ”I! J '\ st} 11: 41"”; {.1L. ,_: . N. J :fli'bdu- as 1,541: a-w-N ”"i’ f E. _ rum-hm “infirm [misc ENE it"s" allergic P65 tusl\!&.*l-'J”il"t\{u find—(fin!1Ww‘4“"(4 Fifi/g rem t... “g”? Caz—HE; W1C? .‘v‘ .,. _..._ —......._.._»..—_v- {‘1' 4%. V 4;: an! £14345" 26. Write a number in each blank to match each term on the left with its most appropriate definition on the right. Each definition should only be used only once or not at all. If; a. erythropoietin l. triggers activation of platelets it b. collagen I 2. substrate for thrombin I C . c. histamine 3. cytokinethat stimulates white blood cell production 3 d. granzyme _gt_ .e. fibrino gen 4. triggers apoptosis in cells 5;. cytokine that stimulates red blood cell production 6. triggers lysis in cells 7. causes 02 to be unloaded from red_blood cells 8. anticoagulant protein 9. allows non-specific immune cells to recognize bacteria 10. increases permeability of capillaries Page 8 of 8 ______ _:___ ______ ______ _____: ®®@®®3,@®®®eg ®®@®®s ®®©©®2 @®@®®3 mouo< mound mound mouo< moum< @®@®®s ©®®®®s ®®@®@2 ®®@®es ®©®®®$ mound wound mound mound mound. ®®@@®3 ®®@@®g ®®@®®: ®®@®ea ®@@®®: wound mouo< mound. wound mound ®®®®®s ®®@®®= ®®®®ez ®®@®®z ®®@®®m mouo< mouo( mouo¢ mound moum< ®®@®@g O®@®®s ®®@®®2 ©9©®®s @®@®®: mound mouo< mouo< mound mound @®@®®g ®®@®©g ®®@®@2 ®®@®®3 ®®@®@£ mouo< mound wound moumq mound. ®®®@®3 ©®©®®a ®@©@®= ®®@®®g @®@®®: mound wound uouoq mound mouma. ®®@®®3 ®®@®®3 [email protected]@®2 ®®@@@s ®®@®®$ mound. mound. wound. mound mound @®©®®g ®®@®®g ®®@®®2 ®©@®eg @®@®®s mound wouo‘1 mound mouo< mound ©9®®®s ®®@®®; ®®@®@= ®®@®ez ®®@@es moum< mound mound mount neona. @®@©®s ®®@®@e ®®@®ea @®®®®a ®®@O®2 mouo< wound mound mound mouoq ®®©®ee @®@®®a ®®@®®g @®©®®2 ©®®®Oa mouo< mound mound mouo< mouni ®®@®®e ®®@®®g ©®®®®a ®®@®®2 ®®@Oeu moum< mound wound mound mound @®@@@= ®®®®Og @®@®®a ©®®®®= ®®O®®h mound. wound uo0o¢ uoumd mouma. ©6®®®e ®®@®©a ®®@®©a ®®@®®2 ®®[email protected]®, mound mound mound moumd mound ®®@®©e ®®@®®g ®®@®®a ®@@®©2 ®[email protected]®®m mound mound mound mouo< mound ®®@®®: ®®@®®g ®®@®ea ®®[email protected]©= @[email protected]®®. mound mound mound. mound moon... ©6©®®9 ©®©®©a ®®@®®2 O®©®®e ®[email protected]®@n mound wound mound uoumd mound ®©@®®: ®®@®®: ®®@®®g ®®O®®2 ®®@O®~ mound mound mound mouo< mound ®®®®es ®®@®®5 ®®@®®a ®®@@O: O®@®®. mound mound mound moum< mound . a mem 20 90:03:52. azimsa 555%. mmm ohm—IQ mm3w2< . moz 2092mm . women—man. ._<m_mzm0 unm%[email protected]@®®®®O®O®9©©®©99 mun-c @‘3 2.2 .3..."— ._ao.= widz _ ...
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