AUTOIMMUNE DISORDERS report

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Click to edit Master subtitle style 9/13/11 AUTOIMMUNE DISORDERS Prepared by: Mark Dino B. Albiela, R.N.
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9/13/11 AUTOIMMUNE DISORDERS A Group of 60 to 80 chronic inflammatory diseases with genetic predisposition and environmental modulation Prevalence of 5% to 8% in US Prevalence is greater for females than males 75% of cases
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9/13/11 RISK FACTORS FOR AUTOIMMUNE DISEASES Genetic (HLA type) Female X chromosome inactivation Environmental Smoking with RA Drugs Procainamide, minocycline, quinidine Infections
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9/13/11 CLASSIFICATION OF Tissue/ Organ Specific Grave’s Disease Myasthenia gravis Not tissue specific, but tend to accumulate forming inflammatory response Acute glomerulonephritis Systemic Systemic lupus erythematosus Rheumatoid arthritis
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9/13/11 Pathophysiology The mechanism that causes immune system to recognize host tissue as foreign is not clear. The following factors are the possible contributors to autoimmune disorders: Release of previously “hidden” antigens into the circulation, such as DNA or other components of cell nucleus Chemical, physical or biologic changes in host tissue that cause self-antigens to stimulate the production of autoantibodies
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9/13/11 Introduction of an antigen, such as bacteria or virus whose antigenic properties closely resemble those of host tissue. A defect in normal cellular immune function that allows the cells to produce antibodies Initiation of the autoimmune response by very slow – growing mycobacteria.
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9/13/11 GRAVES' DISEASE Most common cause of hyperthyroidism (thyrotoxicosis) Incidence of 50-80 cases / 100,000 population / year Female to male ratio of 8:1 Effector mechanisms involve auto- reactive antibodies Thyroid stimulating hormone (TSH) receptor (Thyrotropin receptor)
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9/13/11
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AUTOIMMUNE DISORDERS report - Click to edit Master subtitle...

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