SLE - Systemic Lupus Erythematosus (SLE) Dana Gais...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
Systemic Lupus Erythematosus (SLE) Dana Gais
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Autoimmune Diseases Autoimmune Disease Systemic Autoimmune Disease Responses seen in SLE Autoantibodies found in SLE
Background image of page 2
Systemic Lupus Erythematosus Course of Disease & Causes of Death Clinical Symptoms What causes these symptoms?
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
What Causes SLE Cause is unknown Possible factors Genetic Environmental
Background image of page 4
What Happens? Loss of self-non-self recognition Diversification of antigen-driven responses Formation of immune complexes Type III hypersensitivity reaction
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Loss of T-cell Tolerance T-Cells found in healthy & diseased patients Loss of self-non-self recognition allows T-Cells to react with self antigen
Background image of page 6
Pathogenesis once T-cell tolerance is lost
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Type III Hypersensitivity Reaction (Immune Complex-Mediated) Hyperactivity of T and B-cells Formation of immune complexes Clearance via the complement system Type III Hypersensitivity Reaction Tissue damage
Background image of page 8
Image of page 9
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 11

SLE - Systemic Lupus Erythematosus (SLE) Dana Gais...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online