Lupus Presentation

Lupus Presentation - Systemic Lupus Erythematosus Steve...

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Systemic Lupus Erythematosus Steve Beesley
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History 1948 – Malcolm Hargraves discovers the lupus erythematosus (LE) cell. 1957 – The first anti-DNA antibody is identified.
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LE Cell The LE cell is a neutrophil that has engulfed the antibody-coated nucleus of another neutrophil. LE cells may appear in rosettes where there are several neutrophils vying for an individual complement covered protein.
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Genetic Associations HLA’s are loci on genes that code for certain β chain on the MHC complex HLA-DR2 HLA-DR3 HLA-DQB1 – Involved in mediating production of antibodies to ds-DNA
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Symptoms Non-specific: Fatigue Weight loss Malaise = generally feeling ill Fever Anorexia (over time) Arthritis 90% of patients experience arthritic symptoms Symmetrical Appears in hands, wrists, and knees mainly
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Skin Manifestations Malar or Butterfly Rash Discoid Rash – Stimulated by UV light Skin manifestations only appear in 30- 40% of lupus patients.
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Lupus Presentation - Systemic Lupus Erythematosus Steve...

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