l9_liver_lec

l9_liver_lec - 3/20/2007 Page 1 20.201 Mechanisms of Drug...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
3/20/2007 Page 1 20 .201 Mechanisms of Drug Action The Liver and Metabolism September 30, 2005
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
3/20/2007 Page 2 Distribution of Chemicals to Liver • Chemicals entering blood are distributed in the general circulation via the aorta • Chemicals enter various organs • Focus now on liver Liver anatomy ~ Largest organ and gland (1.5 kg) ~ Structure: lobes (2 large - R and L; 2 small - caudate, quadrate) ~ Blood supply: portal blood flow, 80%; hepatic artery, 20%; outflow into vena cava ~ Bile duct/gall bladder: bile secreted into bile duct/gall bladder; then into duodenum Liver function ~ major metabolic organ in body ~ significant route of xenobiotic excretion ~ exocrine gland: albumin, clotting factors (prothrombin, fibrinogen, factors 7,9,10) lipoproteins, bile ~ storage organ: carbohydrate (glucose buffer), lipids (TG's), blood (up to 1 L reservoir) ~ metabolic functions: gluconeogenesis, amino acid deamination/urea formation, cholesterol synthesis, fatty acid oxidation Epiglottis Mouth Trachea Hepatic Vein* Liver* Gallbladder* Duodenum Portal Vein Veins Bacteria Appendix Anus Stomach Pancreas Small Intestine Large Intestine Salivary Glands Esophagus Flap that closes windpipe during swallowing. Windpipe (not part of digestive system) Stores food and makes chemical changes in it. Vein that carries blood away from liver. Sheltered by the liver, It stores bile. First part of small intestine; bile from liver breaks up fat and juice from pancreas digests all food types. Carries blood from entire digestive tract to liver. Drain intestinal tract, carrying digested food into portal vein. (Represented by dots) live in intestines; make vitamines used by human body. *cross sectional view Grinds food and mixes it with saliva; where digestion begins. Make saliva, start digestion of starch. Passes food from mouth to
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 7

l9_liver_lec - 3/20/2007 Page 1 20.201 Mechanisms of Drug...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online