l9_liver_lec - Page 1 20.201 Mechanisms of Drug Action The...

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3/20/2007 Page 1 20 .201 Mechanisms of Drug Action The Liver and Metabolism September 30, 2005
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3/20/2007 Page 2 Distribution of Chemicals to Liver • Chemicals entering blood are distributed in the general circulation via the aorta • Chemicals enter various organs • Focus now on liver Liver anatomy ~ Largest organ and gland (1.5 kg) ~ Structure: lobes (2 large - R and L; 2 small - caudate, quadrate) ~ Blood supply: portal blood flow, 80%; hepatic artery, 20%; outflow into vena cava ~ Bile duct/gall bladder: bile secreted into bile duct/gall bladder; then into duodenum Liver function ~ major metabolic organ in body ~ significant route of xenobiotic excretion ~ exocrine gland: albumin, clotting factors (prothrombin, fibrinogen, factors 7,9,10) lipoproteins, bile ~ storage organ: carbohydrate (glucose buffer), lipids (TG's), blood (up to 1 L reservoir) ~ metabolic functions: gluconeogenesis, amino acid deamination/urea formation, cholesterol synthesis, fatty acid oxidation Epiglottis Mouth Trachea Hepatic Vein* Liver* Gallbladder* Duodenum Portal Vein Veins Bacteria Appendix Anus Stomach Pancreas Small Intestine Large Intestine Salivary Glands Esophagus Flap that closes windpipe during swallowing. Windpipe (not part of digestive system) Stores food and makes chemical changes in it. Vein that carries blood away from liver. Sheltered by the liver, It stores bile. First part of small intestine; bile from liver breaks up fat and juice from pancreas digests all food types. Carries blood from entire digestive tract to liver. Drain intestinal tract, carrying digested food into portal vein. (Represented by dots) live in intestines; make vitamines used by human body. *cross sectional view Grinds food and mixes it with saliva; where digestion begins. Make saliva, start digestion of starch. Passes food from mouth to
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This note was uploaded on 09/13/2011 for the course ENG 101 taught by Professor Dr.hickenbottom during the Spring '10 term at West Liberty.

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l9_liver_lec - Page 1 20.201 Mechanisms of Drug Action The...

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