Ch%2027%20Male%20Reproduction%20Lecture%20Presentation%20Fall%2c%202011-1

10 mechanismandeffectsoftestosterone

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Unformatted text preview: Sertoli cells and BTB The Sustentacular cells protect the germ cells and promote their development. Tight junctions between adjacent sustentacular cells form a blood­testis barrier (BTB) The fluid inside the tubules contains high levels of androgens, potassium and amino acids The BTB prevents the immune system from attacking the developing spermatozoa (contain specific Ag that are not found on any other cell) Sertoli cell supply nutrients to the developing sperms Phagocytize cytoplasm shed by spermatids Secrete inhibin (we will talk about this hormone later) Secrete androgen­binding­protein (ABP) – binds testosterone inside tubules to maintain high levels Hormonal Regulation of Hormonal Regulation of Testicular Function The hypothalamus releases gonadotropin­ releasing hormone (GnRH) GnRH stimulates the anterior pituitary to secrete FSH and LH FSH causes sustentacular cells to release androgen­ binding protein (ABP) LH st...
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