Ch%2027%20Male%20Reproduction%20Lecture%20Presentation%20Fall%2c%202011-1

Tight junctions between adjacent sustentacular

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Unformatted text preview: er with tight junctions forming an unbroken layer with the seminiferous tubule, dividing it into two compartments: Basal compartment – contains spermatogonia and primary spermatocytes Adluminal compartment – contains meiotically active cells and the tubule lumen Sustentacular Cells Sustentacular Cells Their tight junctions form a blood­testis barrier ­­­­prevents sperm antigens from escaping through the basal lamina into the blood Since sperm are not formed until puberty, they are absent during thymic education ­­ What does this have to do with sperm?? Spermatogonia are recognized as “self” and are influenced by bloodborne chemical messengers that prompt spermatogenesis Adluminal Compartment Adluminal Compartment Activities Spermatocytes and spermatids are nearly enclosed in sustentacular cells, which: Deliver nutrients to dividing cells Move them along to the lumen Secrete testicular fluid that provides the transport medium for sperm Dispose of excess cytoplasm sloughed off during maturation to sperm Produce chemical mediators that help regulate spermatogenesis The functions of...
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