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Biology: A Guide to the Natural World with mybiology" (4th Edition)

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KroghF09.012 Molecular Genetics Feb. 25, 2011 Topic 10: Molecular Genetics I. Discovering the Structure of DNA A. The necessary properties of Mendel’s “Factors” (AKA “Genes”) 1. Store and provide information that controls the development, growth and daily activity of organisms 2. Must be able to be replicated accurately by dividing cells 3. Must permit occasional change B. The evidence available: 1. X-Ray Diffraction pictures showing repeating units (Fig. 13.2) 2. Knowledge of the chemical make-up of Nucleotides 3. Chagraff’s Rule: A = T and C = G C. The Model: Watson and Crick’s Double Helix (1953) (Review) (Fig. 13.1) 1. DNA consists of two strands of nucleotides (Fig. 13.3) 2. Nucleotides joined by sugar-phosphate bonds 3. Strands cross-connected by Complementary Base Pairs : A with T, C with G D. The Human Genome 1. Average human chromosome has 140 million base pairs 2. Human genome is about 3 Billion base pairs (in each cell!) 3. Genome organized into about 25,000 genes
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Topic10-MolecularEvololution - KroghF09.012 Molecular...

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