Exam Three - 2003

Exam Three - 2003 - Biology 310, Cell Biology Third Midterm...

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Biology 310, Cell Biology Third Midterm Examination Spring 2003 Name: [Print]____________________________ Student ID#______________________ Name: [Signature]___________________________________ Write in INK ; examinations written in pencil or erasable ink will not be read. DO NOT USE DIAGRAMS IN ANY ANSWER. If your handwriting is poor, PRINT your answers; illegible answers will not be read. The value of each question is shown in parentheses. THINK before you write anything. Write clear, concise, brief answers. 1. a. What are cyclins and what role[s] do they play in the cell cycle? [One-two sentences] [4] b . What role do proteosomes play with regard to the function of cyclins? [One sentence] [2] 2. a. What is the Anaphase Promoting Complex? [One sentence] [2] b. What role do proteosomes play in the activity of the Anaphase Promoting Complex? [2] [One Sentence] 3 . a .P 53 is responsible for three main aspects of cellular events. What are they? [3] [Three phrases] b . P 53 causes the transcription of P 2 1 . What does P 21 do? [2] [One sentence] c. P 53 is regulated by Mdm2 . What is Mdm2 and how does it regulate P 53 ? [4] One-two sentences] d . P 53 can also bind to Bcl-2 . What is the result of this binding? [2] [One-two sentences] e . What three processes regulate P 53 in cells ? [3] 4.a. In what two ways does the RB protein regulate the cell cycle? [Two phrases] b . What is the effect of phosphorylation of the RB protein on its functions? [2]
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5 . List five properties of transformed cells. [5] 6. Cellular transformation is described as a “two hit” event. What are the two “hits”? [2] 7. a. A cell biologist working with cells of the red-breasted wombat noticed that the cells would die when exposed to the ligand CD 95 or FAS. The dying cells had the following characteristics:
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Exam Three - 2003 - Biology 310, Cell Biology Third Midterm...

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