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Exam Three - 2006 - Biology 310 Cell Biology Third Midterm...

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Biology 310 Cell Biology Third Midterm Examination Spring 2006 Name: [Print Clearly]_____________ Student Number____________________ Name: [Signature]______________________ Write in INK . Examinations written in pencil or erasable ink will not be read and a failing grade will be assigned. DO NOT USE DIAGRAMS FOR ANY ANSWER. The value of each question is shown in parentheses. If your handwriting is poor, PRINT , your answers. Illegible answers will not be read and will be given a score of zero. Use the back of the pages to write or print your answers if you do not have enough room on the front of the exam. Think before you write. Make your answers concise and correct. Ask yourself what the question is really asking . Take your time . We will use the entire 2 1/2 hours for the exam, even though it is written as an 80 minute examination . 1. a. Define Caspase _: b.One of the genes of the cowpox virus encodes a protein, CrmA that is a potent inhibitor of caspases. What effect would this inhibitor have on a cell infected with the virus? [1] c. Why does this gene give an advantage to the virus? [1] 2. During apoptosis what structural event occurs to prevent an inflammatory response? [2] 3. In mice a mutation of caspase 9 causes the mice to die as a result of a number of defects including a greatly enlarged brain . What is the cause of this phenotype? [One sentence] [2] . 4. What molecular characteristic of cytochrome c allows it to be readily released from mitochondria upon receipt of an apoptotic signal? [One sentence] [2] 5. What two roles does P53 play in apoptosis? [One-two sentences or phrases] a. ___ . b. _____ 6. Cells of the red-breasted woodchuck underwent extensive DNA damage and had a mutation of Mdm-2. What would be the result of this? Include in your answer the role of Mdm-2. [2] 7. Damaged cells of the ring-tailed baboon showed the following characteristics:
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Phosphatidylserine concentrated on the inner leaflet of cell membranes, high NAD+ activity, low ATP, and increased PARP [poly{ADP ribose}polymerase] activity. Will these cells die by necrosis or apoptosis ? ___________ ____________________________________ [1] 8. A Stony Brook student was growing some cells of the hawk-eyed pigeon when she noted that the cells had stopped growing with short telomeres. She noted that P53 and P21 were up-regulated. a. What would happen with respect to cell division if P53 were inactivated? [1] b. What would happen with respect to cell division if P16 were activated? [1] . 9. Does caloric restriction raise or lower the production of reactive oxygen species[ROS]? a. __________ _____________________ [1] 0. Do uncoupling proteins increase or decrease the production of ROS? b. ______________ _________________________ [1] 11. Under what circumstances is the production of ROS beneficial? [One sentence][2] 12. Why do cloned organisms show age related characteristics? [One-two sentences] [2] -2- 13. Food intake results in activation of insulin-like growth factor [IGF-1] and an increase in P 53 activity. What would be the effect of this on: c. Cell division.[promote or inhibit? ______ ________________ [1] d. Senescence [promote or inhibit?] _______ ______________ [1] e. Tumor suppression [promote or inhibit] _____ __________ [1] f. Aging [promote or inhibit? ________________ __________ [1] 14. Multi-cellular organisms with renewable cell populations are prone to damage from the
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