Exam Three - 2007

Exam Three - 2007 - Biology 310 Third Midterm Examination...

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Biology 310 Third Midterm Examination Spring 2007 Name: [Print]_________Key________________ Name:[Signature]____________________ Student number___________________________ Instructions: Write in INK. Examinations written in pencil or erasable ink will not be read and a failing grade will be assigned. DO NOT USE DIAGRAMS FOR ANY ANSWER. The value of each question is shown in parentheses. If your handwriting is poor, PRINT your answers. Illegible answers will not be read and will be given a score of ZERO . Use the back of the pages to write or print your answers if you do not have enough room on the front of the exam. THINK before you write. Make your answers concise and correc t. Ask yourself what the question is really asking. Take your time. We will use the entire 21/2 hours for the exam, even though it has been written as a 60 minute exam. You will note that we are suggesting limits on the amount of writing needed for many answers. This is to prevent excess verbosity. Some students feel if they write everything they can think of for a question we will find some piece of the answer buried in there. We discourage such a practice. _____________________________________________ 1. A culture of cells grown from the red-crested wombat were found to have undergone extensive DNA damage and had a mutation of Mdm-2. a. What is the function of Mdm-2? [1] b. Will P53 be activated or inactivated? _______ ________ [1] c. Will the cells be driven toward apoptosis? [ YES or NO ] ___ ____ [1] d. Will cytochrome c be released into the cytoplasm? [ Yes or No ] __ ___- [1] e. What characteristic of cytochrome c makes it readily released into the cytoplasm. [2] [One sentence] f. What two functions does P53 play in apoptosis? [2] 1. _______ _______ 2. ______ ______ -1- 2. Two cell biologists were working on a cure for breast cancer. They noted that there are estrogen receptors in the cytoplasm and on the mitochondrial surface. Estrogen can promote cell division in mammary tumors and induce the activation of carbonic
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dismutase. They decided to induce the formation of reactive oxygen species [ROS] in the mitochondria as a means of killing tumor cells. a. What is the effect of ROS on tumor cells? [1] [One sentence] b. What effect does estrogen have on ROS [1] [One sentence] . c. Would the induction of ROS kill the mammary tumor cells? [ Yes or No ] __ __ [1] d. Why or Why not? [One-two sentences] [1] 3. Cells under stress [i.e DNA damage] must balance between necrosis and apoptosis. With extensive and excessive DNA damage PARP[Poly [ADP-ribose polymerase] is activated. a. What is the effect of this on the cellular concentrations of NAD+ and ATP? [One sentence] [1] . b. Will the cell undergo necrosis or apoptosis? _____ ___________________[1] c. What is the reason for your answer to b.? [One –two sentences] [1] 4. Some receptors can cause cell death while others may promote survival even in the presence of cellular stress. The IL receptor activated by binding Il induces the
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This note was uploaded on 09/14/2011 for the course BIO 310 taught by Professor Lyman during the Spring '08 term at SUNY Stony Brook.

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Exam Three - 2007 - Biology 310 Third Midterm Examination...

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