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Exam Three - 2008 - Biology 310 Third Midterm Examination...

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Biology 310 Third Midterm Examination Spring 2008 Name: [Print]________KEY_______________ Name:[Signature]____________________ Student number___________________________ Instructions: Write in INK. Examinations written in pencil or erasable ink will not be read and a failing grade will be assigned. DO NOT USE DIAGRAMS FOR ANY ANSWER. The value of each question is shown in parentheses. If your handwriting is poor, PRINT your answers. Illegible answers will not be read and will be given a score of ZERO . Use the back of the pages to write or print your answers if you do not have enough room on the front of the exam. THINK before you write. Make your answers concise and correc t. Ask yourself what the question is really asking. Take your time. We will use the entire 21/2 hours for the exam, even though it has been written as a 60 minute exam. You will note that we are suggesting limits on the amount of writing needed for many answers. This is to prevent excess verbosity. Some students feel if they write everything they can think of for a question we will find some piece of the answer buried in there. We discourage such a practice. _____________________________________________ 1. Canine kidney cells were grown in culture. It was noticed that they divided 40 times and then stopped dividing. It was noted the expression of the transcription factors jun and fos and E2F was repressed. a. Were these cells senescent or quiescent? ______ _______- [1] b. If p53 were inactivated could these cells rejoin the cell cycle? [Yes,No]___ ___ [1] c. Would telomerase be active in these cells? [Yes/No] ______ _______________ [1] d. Would Mdm2 be active or inactive in these cell? _________ ____________ [1] e. What is the function of Mdm2? [One sentence] [2] 2. The cell cycle is regulated by an interplay between cyclins and cdks. a. What is the role of cyclins with respect to cdks? [One sentence] [1] b. How does the APC/C regulate the activity of cyclins? [one sentence] [1] c. CKI is an inhibitor of cdks which itself is regulated by SCF. How does SCF regulate CKI? . [1] -1-
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3. a. What is unique about the kinesins in the mitotic spindle? [One sentence] [1] b.What role does dynein play in the mitotic spindle? [One sentence] [1] 4. A mutation in cells of yellow hamsters leads to a phenotype in which the following is seen: In some cells duplicated chromatids do not separate and move to only one pole. In other cells some chromatids are not attached to the spindle. The mutations were traced to some kinetochore proteins a. What was the cause of the phenotypes described here? [One-two sentences] [2] 5. Red-crested wombats suffer from aging neurogenerative diseases. Their neurons can be grown in cell culture; they divide 20 times and then die. Transfection of the cells with SIRT [ a member of the Sirtuins family of proteins] allows the cells to keep dividing, but they eventually die. Researchers studied the wombats and their neurons in culture. They noticed that putting the wombats on a low calorie diet increased their life span, but did not block the eventual onset of neurogenerative disease.
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