Exam Three - 2010

Exam Three - 2010 - Biology 310 Third Midterm Examination...

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Biology 310 Third Midterm Examination Spring 2010 Name: [Print]________________________ Name:[Signature]____________________ Student number___________________________ Instructions: Write in INK. Examinations written in pencil or erasable ink will not be read and a failing grade will be assigned. DO NOT USE DIAGRAMS FOR ANY ANSWER. The value of each question is shown in parentheses. If your handwriting is poor, PRINT your answers. Illegible answers will not be read and will be given a score of ZERO . Use the back of the pages to write or print your answers if you do not have enough room on the front of the exam. THINK before you write. Make your answers concise and correc t. Ask yourself what the question is really asking. Take your time. We will use the entire 21/2 hours for the exam, even though it has been written as a 60 minute exam. You will note that we are suggesting limits on the amount of writing needed for many answers. This is to prevent excess verbosity. Some students feel if they write everything they can think of for a question we will find some piece of the answer buried in there. We discourage such a practice. _____________________________________________ 1. As cells exit mitosis several events are regulated by the eleven subunit APC complex. a. What is the APC complex and how does it regulate the components of the cell cycle at the end of mitosis. [One-two sentences] [ 2 ] b. How is the interaction of cyclins and Cdks regulated? [ 2 ] [One-two sentences] 2. A mutation was found in yeast cells in which the cells could not proceed beyond the G 1 phase of the cell cycle. The mutation was traced to a ubiquitin ligase. a. What is a ubiquitin ligase? [One sentence] [ 1 ] b. Why would a mutation of an ubiquitin ligase block the cell cycle beyond the G 1 phase? [One-two sentences] [ 2 ]
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3. In marmoset cells a mutation causes a failure the kinetochore of chromosome #6 to attach to the spindle. a. What is a kinetochore? [One sentence ] [ 1 ] b. What G-protein is involved in chromosome-kinetochore attachment ? [ 1 ] c. One consequence of the mutation was the activation of caspase 9. 1. What is caspase 9? [One sentence] [ 1 ] 2. What is the result of caspase 9 activation? [One sentence ] [ 1 ] 4. a. What elements of the cytoskeleton are required for cytokinesis? [ 4 ] b. Why would a mutation of separase prevent cytokinesis? [ 1 ] [One sentence ] 5. Some students were investigating the roles of the cytoskeleton in muscle cell division and injected antibodies to Myosin II into dividing muscle cells. a. With which component of the cytoskeleton would Myosin II be associated? [ 1 ] b. What aspect of cell division would be specifically affected by the injection of myosin II antibodies? [ 1 ] 6. In animal cells what determines the location of the division furrow? [ 1 ] [One sentence] 7. During embryonic development of the nematode asymmetric cell division must occur or organ formation is aberrant. a. How is the mitotic spindle “captured” to regulate asymmetric cell division?
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Exam Three - 2010 - Biology 310 Third Midterm Examination...

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