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Exam Three Key - 2006

Exam Three Key - 2006 - Biology 310 Cell Biology Third...

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Biology 310 Cell Biology Third Midterm Examination Spring 2006 Name: [Print Clearly]_____Key________ Student Number____________________ Name: [Signature]______________________ Write in INK . Examinations written in pencil or erasable ink will not be read and a failing grade will be assigned. DO NOT USE DIAGRAMS FOR ANY ANSWER. The value of each question is shown in parentheses. If your handwriting is poor, PRINT , your answers. Illegible answers will not be read and will be given a score of zero. Use the back of the pages to write or print your answers if you do not have enough room on the front of the exam. Think before you write. Make your answers concise and correct. Ask yourself what the question is really asking . Take your time . We will use the entire 2 1/2 hours for the exam, even though it is written as an 80 minute examination . 1. a. Define Caspase _: Cysteine-aspartic acid specific-protease induced during apoptosis [1] b.One of the genes of the cowpox virus encodes a protein, CrmA that is a potent inhibitor of caspases. What effect would this inhibitor have on a cell infected with the virus? [1] The cell would not undergo apoptosis c. Why does this gene give an advantage to the virus? [1] The virus needs the cell alive in order to reproduce. In apoptosis the viral DNA would be destroyed along with the cell 2. During apoptosis what structural event occurs to prevent an inflammatory response? [2] The cell forms membrane bound apoptotic bodies; thus no material escapes. 3. In mice a mutation of caspase 9 causes the mice to die as a result of a number of defects including a greatly enlarged brain . What is the cause of this phenotype? [One sentence] [2] Excess neurons normally generated during development did not undergo apoptosis. 4. What molecular characteristic of cytochrome c allows it to be readily released from mitochondria upon receipt of an apoptotic signal? [One sentence] [2] Cytochrome C is a peripheral protein of the electron transport chain that is between the inner and outer membranes 5. What two roles does P53 play in apoptosis? [One-two sentences or phrases] a. ___ Stimulation of transcription of “death” genes: PUMA,NOXA_______[1] Activate Bax, Bad. Stimulates transcription of P21. b. _____ Aids the release of apoptotic factors from mitochondria;inhibits Bcl-2,Bcl-X L [1] Specific molecules must be mentioned for full credit. -1-
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6. Cells of the red-breasted woodchuck underwent extensive DNA damage and had a mutation of Mdm-2. What would be the result of this? Include in your answer the role of Mdm-2. [2] The result would be apoptosis. Mdm-2 and P53 form a complex such that P53 is inactive. An Mdm-2 mutation would release P53 promoting apoptosis. 7.
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Exam Three Key - 2006 - Biology 310 Cell Biology Third...

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