Exam Three Key - 2008

Exam Three Key - 2008 - Biology 310 Third Midterm...

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Biology 310 Third Midterm Examination Spring 2008 Name: [Print]________KEY_______________ Name:[Signature]____________________ Student number___________________________ Instructions: Write in INK. Examinations written in pencil or erasable ink will not be read and a failing grade will be assigned. DO NOT USE DIAGRAMS FOR ANY ANSWER. The value of each question is shown in parentheses. If your handwriting is poor, PRINT your answers. Illegible answers will not be read and will be given a score of ZERO . Use the back of the pages to write or print your answers if you do not have enough room on the front of the exam. THINK before you write. Make your answers concise and correc t. Ask yourself what the question is really asking. Take your time. We will use the entire 21/2 hours for the exam, even though it has been written as a 60 minute exam. You will note that we are suggesting limits on the amount of writing needed for many answers. This is to prevent excess verbosity. Some students feel if they write everything they can think of for a question we will find some piece of the answer buried in there. We discourage such a practice. _____________________________________________ 1. Canine kidney cells were grown in culture. It was noticed that they divided 40 times and then stopped dividing. It was noted the expression of the transcription factors jun and fos and E2F was repressed. a. Were these cells senescent or quiescent? ______ Senescent________- [1] b. If p53 were inactivated could these cells rejoin the cell cycle? [Yes,No]___ Yes___ [1] c. Would telomerase be active in these cells? [Yes/No] ______ No_______________ [1] d. Would Mdm2 be active or inactive in these cell? _________ Active____________ [1] e. What is the function of Mdm2? [One sentence] Mdm2 regulates p53 by tagging it for destruction; it thus maintains p53 homeostasis [2] 2. The cell cycle is regulated by an interplay between cyclins and cdks. a. What is the role of cyclins with respect to cdks? [One sentence] Cyclins bind and activate the kinase activity of cdks [1] b. How does the APC/C regulate the activity of cyclins? [one sentence] APC/C is a ubiquitin ligase that regulates the destruction of cyclins in proteosomes [1] c. CKI is an inhibitor of cdks which itself is regulated by SCF. How does SCF regulate CKI? SCF is a ubiquitin ligase which would tag CKI for destruction in proteosomes . [1] -1-
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3. a. What is unique about the kinesins in the mitotic spindle? [One sentence] [1] The kinesins of the mitotic spindle can move in both plus and minus directions b.What role does dynein play in the mitotic spindle? [One sentence] [1] Dyneins anchor the microtubles of the spindle to the plasma membrane. Or:
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This note was uploaded on 09/14/2011 for the course BIO 310 taught by Professor Lyman during the Spring '08 term at SUNY Stony Brook.

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Exam Three Key - 2008 - Biology 310 Third Midterm...

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